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Fusion gene ID: 28330 |
FusionGeneSummary for PPP1R13B_ZP3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPP1R13B_ZP3 | Fusion gene ID: 28330 | Hgene | Tgene | Gene symbol | PPP1R13B | ZP3 | Gene ID | 23368 | 7784 |
| Gene name | protein phosphatase 1 regulatory subunit 13B | zona pellucida glycoprotein 3 | |
| Synonyms | ASPP1|p53BP2-like|p85 | OOMD3|ZP3A|ZP3B|ZPC|Zp-3 | |
| Cytomap | 14q32.33 | 7q11.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | apoptosis-stimulating of p53 protein 1apoptosis-stimulating protein of p53, 1protein phosphatase 1, regulatory (inhibitor) subunit 13B | zona pellucida sperm-binding protein 3ZP3A/ZP3Bsperm receptorzona pellucida glycoprotein 3Bzona pellucida glycoprotein ZP3zona pellucida protein C | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q96KQ4 | P21754 | |
| Ensembl transtripts involved in fusion gene | ENST00000202556, ENST00000423488, ENST00000555391, | ENST00000336517, ENST00000394857, ENST00000416245, ENST00000467555, | |
| Fusion gene scores | * DoF score | 8 X 3 X 6=144 | 4 X 4 X 4=64 |
| # samples | 9 | 4 | |
| ** MAII score | log2(9/144*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PPP1R13B [Title/Abstract] AND ZP3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PPP1R13B | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator | 11684014 |
| Tgene | ZP3 | GO:0002922 | positive regulation of humoral immune response | 19004505 |
| Tgene | ZP3 | GO:0007339 | binding of sperm to zona pellucida | 19246320|19700799 |
| Tgene | ZP3 | GO:2000344 | positive regulation of acrosome reaction | 11751269|18667750|20394732 |
| Tgene | ZP3 | GO:2000360 | negative regulation of binding of sperm to zona pellucida | 18667750 |
| Tgene | ZP3 | GO:2000368 | positive regulation of acrosomal vesicle exocytosis | 19246320 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCEC | TCGA-AJ-A6NU-01A | PPP1R13B | chr14 | 104313636 | - | ZP3 | chr7 | 76054369 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000202556 | ENST00000336517 | PPP1R13B | chr14 | 104313636 | - | ZP3 | chr7 | 76054369 | + |
| 5CDS-5UTR | ENST00000202556 | ENST00000394857 | PPP1R13B | chr14 | 104313636 | - | ZP3 | chr7 | 76054369 | + |
| 5CDS-intron | ENST00000202556 | ENST00000416245 | PPP1R13B | chr14 | 104313636 | - | ZP3 | chr7 | 76054369 | + |
| 5CDS-intron | ENST00000202556 | ENST00000467555 | PPP1R13B | chr14 | 104313636 | - | ZP3 | chr7 | 76054369 | + |
| intron-5UTR | ENST00000423488 | ENST00000336517 | PPP1R13B | chr14 | 104313636 | - | ZP3 | chr7 | 76054369 | + |
| intron-5UTR | ENST00000423488 | ENST00000394857 | PPP1R13B | chr14 | 104313636 | - | ZP3 | chr7 | 76054369 | + |
| intron-intron | ENST00000423488 | ENST00000416245 | PPP1R13B | chr14 | 104313636 | - | ZP3 | chr7 | 76054369 | + |
| intron-intron | ENST00000423488 | ENST00000467555 | PPP1R13B | chr14 | 104313636 | - | ZP3 | chr7 | 76054369 | + |
| intron-5UTR | ENST00000555391 | ENST00000336517 | PPP1R13B | chr14 | 104313636 | - | ZP3 | chr7 | 76054369 | + |
| intron-5UTR | ENST00000555391 | ENST00000394857 | PPP1R13B | chr14 | 104313636 | - | ZP3 | chr7 | 76054369 | + |
| intron-intron | ENST00000555391 | ENST00000416245 | PPP1R13B | chr14 | 104313636 | - | ZP3 | chr7 | 76054369 | + |
| intron-intron | ENST00000555391 | ENST00000467555 | PPP1R13B | chr14 | 104313636 | - | ZP3 | chr7 | 76054369 | + |
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FusionProtFeatures for PPP1R13B_ZP3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPP1R13B | ZP3 |