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Fusion gene ID: 28292 |
FusionGeneSummary for PPP1R10_PCED1A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPP1R10_PCED1A | Fusion gene ID: 28292 | Hgene | Tgene | Gene symbol | PPP1R10 | PCED1A | Gene ID | 5514 | 64773 |
| Gene name | protein phosphatase 1 regulatory subunit 10 | PC-esterase domain containing 1A | |
| Synonyms | CAT53|FB19|PNUTS|PP1R10|R111|p99 | C20orf81|FAM113A|bA12M19.1 | |
| Cytomap | 6p21.33 | 20p13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein phosphatase 1 regulatory subunit 10HLA-C associated transcript 53MHC class I region proline-rich protein CAT53PP1-binding protein of 114 kDaphosphatase 1 nuclear targeting subunitprotein phosphatase 1, regulatory (inhibitor) | PC-esterase domain-containing protein 1Afamily with sequence similarity 113, member Asarcoma antigen NY-SAR-23 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q96QC0 | Q9H1Q7 | |
| Ensembl transtripts involved in fusion gene | ENST00000376511, ENST00000484449, ENST00000420949, ENST00000549281, ENST00000468706, ENST00000449113, ENST00000547333, ENST00000475926, ENST00000426299, ENST00000551493, ENST00000494003, ENST00000383586, ENST00000548899, ENST00000478528, ENST00000424446, ENST00000552146, ENST00000488513, ENST00000429597, ENST00000549865, ENST00000482076, | ENST00000360652, ENST00000356872, | |
| Fusion gene scores | * DoF score | 5 X 4 X 3=60 | 2 X 2 X 1=4 |
| # samples | 5 | 3 | |
| ** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/4*10)=2.90689059560852 | |
| Context | PubMed: PPP1R10 [Title/Abstract] AND PCED1A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PPP1R10 | GO:0010667 | negative regulation of cardiac muscle cell apoptotic process | 23426265 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CN412070 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000376511 | ENST00000360652 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000376511 | ENST00000356872 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000484449 | ENST00000360652 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000484449 | ENST00000356872 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000420949 | ENST00000360652 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000420949 | ENST00000356872 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000549281 | ENST00000360652 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000549281 | ENST00000356872 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000468706 | ENST00000360652 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000468706 | ENST00000356872 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000449113 | ENST00000360652 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000449113 | ENST00000356872 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000547333 | ENST00000360652 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000547333 | ENST00000356872 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000475926 | ENST00000360652 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000475926 | ENST00000356872 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000426299 | ENST00000360652 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000426299 | ENST00000356872 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000551493 | ENST00000360652 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000551493 | ENST00000356872 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000494003 | ENST00000360652 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000494003 | ENST00000356872 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000383586 | ENST00000360652 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000383586 | ENST00000356872 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000548899 | ENST00000360652 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000548899 | ENST00000356872 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000478528 | ENST00000360652 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000478528 | ENST00000356872 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000424446 | ENST00000360652 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000424446 | ENST00000356872 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000552146 | ENST00000360652 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000552146 | ENST00000356872 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000488513 | ENST00000360652 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000488513 | ENST00000356872 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000429597 | ENST00000360652 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000429597 | ENST00000356872 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000549865 | ENST00000360652 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000549865 | ENST00000356872 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000482076 | ENST00000360652 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
| intron-3CDS | ENST00000482076 | ENST00000356872 | PPP1R10 | chr6 | 1902621 | - | PCED1A | chr20 | 2819348 | - |
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FusionProtFeatures for PPP1R10_PCED1A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPP1R10 | PCED1A |