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Fusion gene ID: 28264 |
FusionGeneSummary for PPM1K_LRPPRC |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPM1K_LRPPRC | Fusion gene ID: 28264 | Hgene | Tgene | Gene symbol | PPM1K | LRPPRC | Gene ID | 152926 | 10128 |
| Gene name | protein phosphatase, Mg2+/Mn2+ dependent 1K | leucine rich pentatricopeptide repeat containing | |
| Synonyms | BDP|MSUDMV|PP2Ckappa|PP2Cm|PTMP|UG0882E07 | CLONE-23970|GP130|LRP130|LSFC | |
| Cytomap | 4q22.1 | 2p21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein phosphatase 1K, mitochondrialPP2C domain-containing protein phosphatase 1KPP2C-kappaPP2C-type mitochondrial phosphoprotein phosphatasebranched-chain I+/--ketoacid dehydrogenase phosphatasebranched-chain alpha-ketoacid dehydrogenase phosphatas | leucine-rich PPR motif-containing protein, mitochondrial130 kDa leucine-rich proteinLRP 130leucine-rich PPR-motif containingmitochondrial leucine-rich PPR motif-containing protein | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q8N3J5 | P42704 | |
| Ensembl transtripts involved in fusion gene | ENST00000608933, ENST00000295908, ENST00000508256, ENST00000506423, ENST00000315194, ENST00000514204, | ENST00000260665, ENST00000409946, ENST00000409659, | |
| Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 6 X 6 X 1=36 |
| # samples | 3 | 6 | |
| ** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/36*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PPM1K [Title/Abstract] AND LRPPRC [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF090448 | PPM1K | chr4 | 89182212 | - | LRPPRC | chr2 | 44115688 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000608933 | ENST00000260665 | PPM1K | chr4 | 89182212 | - | LRPPRC | chr2 | 44115688 | - |
| intron-intron | ENST00000608933 | ENST00000409946 | PPM1K | chr4 | 89182212 | - | LRPPRC | chr2 | 44115688 | - |
| intron-intron | ENST00000608933 | ENST00000409659 | PPM1K | chr4 | 89182212 | - | LRPPRC | chr2 | 44115688 | - |
| intron-3UTR | ENST00000295908 | ENST00000260665 | PPM1K | chr4 | 89182212 | - | LRPPRC | chr2 | 44115688 | - |
| intron-intron | ENST00000295908 | ENST00000409946 | PPM1K | chr4 | 89182212 | - | LRPPRC | chr2 | 44115688 | - |
| intron-intron | ENST00000295908 | ENST00000409659 | PPM1K | chr4 | 89182212 | - | LRPPRC | chr2 | 44115688 | - |
| intron-3UTR | ENST00000508256 | ENST00000260665 | PPM1K | chr4 | 89182212 | - | LRPPRC | chr2 | 44115688 | - |
| intron-intron | ENST00000508256 | ENST00000409946 | PPM1K | chr4 | 89182212 | - | LRPPRC | chr2 | 44115688 | - |
| intron-intron | ENST00000508256 | ENST00000409659 | PPM1K | chr4 | 89182212 | - | LRPPRC | chr2 | 44115688 | - |
| intron-3UTR | ENST00000506423 | ENST00000260665 | PPM1K | chr4 | 89182212 | - | LRPPRC | chr2 | 44115688 | - |
| intron-intron | ENST00000506423 | ENST00000409946 | PPM1K | chr4 | 89182212 | - | LRPPRC | chr2 | 44115688 | - |
| intron-intron | ENST00000506423 | ENST00000409659 | PPM1K | chr4 | 89182212 | - | LRPPRC | chr2 | 44115688 | - |
| intron-3UTR | ENST00000315194 | ENST00000260665 | PPM1K | chr4 | 89182212 | - | LRPPRC | chr2 | 44115688 | - |
| intron-intron | ENST00000315194 | ENST00000409946 | PPM1K | chr4 | 89182212 | - | LRPPRC | chr2 | 44115688 | - |
| intron-intron | ENST00000315194 | ENST00000409659 | PPM1K | chr4 | 89182212 | - | LRPPRC | chr2 | 44115688 | - |
| intron-3UTR | ENST00000514204 | ENST00000260665 | PPM1K | chr4 | 89182212 | - | LRPPRC | chr2 | 44115688 | - |
| intron-intron | ENST00000514204 | ENST00000409946 | PPM1K | chr4 | 89182212 | - | LRPPRC | chr2 | 44115688 | - |
| intron-intron | ENST00000514204 | ENST00000409659 | PPM1K | chr4 | 89182212 | - | LRPPRC | chr2 | 44115688 | - |
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FusionProtFeatures for PPM1K_LRPPRC |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPM1K | LRPPRC |