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Fusion gene ID: 28236 |
FusionGeneSummary for PPM1E_SPAG5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPM1E_SPAG5 | Fusion gene ID: 28236 | Hgene | Tgene | Gene symbol | PPM1E | SPAG5 | Gene ID | 22843 | 10615 |
| Gene name | protein phosphatase, Mg2+/Mn2+ dependent 1E | sperm associated antigen 5 | |
| Synonyms | CaMKP-N|POPX1|PP2CH|caMKN | DEEPEST|MAP126|hMAP126 | |
| Cytomap | 17q22 | 17q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein phosphatase 1Eca(2+)/calmodulin-dependent protein kinase phosphatase NcaMKP-nucleusnuclear calmodulin-dependent protein kinase phosphatasepartner of PIX 1partner of PIX-alphapartner of PIXAprotein phosphatase 1E (PP2C domain containing) | sperm-associated antigen 5astrinmitotic spindle associated protein p126mitotic spindle coiled-coil related protein | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q8WY54 | Q96R06 | |
| Ensembl transtripts involved in fusion gene | ENST00000308249, | ENST00000321765, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 4 X 6 X 5=120 |
| # samples | 3 | 7 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PPM1E [Title/Abstract] AND SPAG5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PPM1E | GO:0006469 | negative regulation of protein kinase activity | 11864573 |
| Hgene | PPM1E | GO:0035690 | cellular response to drug | 20801214 |
| Hgene | PPM1E | GO:0035970 | peptidyl-threonine dephosphorylation | 20801214 |
| Hgene | PPM1E | GO:0051496 | positive regulation of stress fiber assembly | 11864573 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-OL-A5RZ-01A | PPM1E | chr17 | 57043254 | + | SPAG5 | chr17 | 26913200 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000308249 | ENST00000321765 | PPM1E | chr17 | 57043254 | + | SPAG5 | chr17 | 26913200 | - |
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FusionProtFeatures for PPM1E_SPAG5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPM1E | SPAG5 |