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Fusion gene ID: 28211

FusionGeneSummary for PPIL3_NEMF

Fusion gene summary

Fusion gene information	Fusion gene name: PPIL3_NEMF
	Fusion gene ID: 28211
		Hgene	Tgene
	Gene symbol	PPIL3	NEMF
	Gene ID	53938	9147
	Gene name	peptidylprolyl isomerase like 3	nuclear export mediator factor
	Synonyms	CYPJ	NY-CO-1\|SDCCAG1
	Cytomap	2q33.1	14q21.3
	Type of gene	protein-coding	protein-coding
	Description	peptidyl-prolyl cis-trans isomerase-like 3PPIasePPIase-like protein 3cyclophilin Jcyclophilin-like protein 3cyclophilin-like protein PPIL3peptidylprolyl cis-trans isomerase-like protein 3peptidylprolyl isomerase (cyclophilin)-like 3rotamase PPIL3	nuclear export mediator factor NEMFantigen NY-CO-1serologically defined colon cancer antigen 1
	Modification date	20180523	20180523
	UniProtAcc	Q9H2H8	O60524
	Ensembl transtripts involved in fusion gene	ENST00000286175, ENST00000392283, ENST00000465823, ENST00000409361, ENST00000409449,	ENST00000298310, ENST00000382135, ENST00000545773, ENST00000556925, ENST00000546046, ENST00000556672,
Fusion gene scores	* DoF score	2 X 2 X 1=4	8 X 11 X 2=176
	# samples	2	13
	** MAII score	log2(2/4*10)=2.32192809488736	log2(13/176*10)=-0.437063805608843 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PPIL3 [Title/Abstract] AND NEMF [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			AK027315	PPIL3	chr2	201736043	-	NEMF	chr14	50065705	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000286175	ENST00000298310	PPIL3	chr2	201736043	-	NEMF	chr14	50065705	+
intron-intron	ENST00000286175	ENST00000382135	PPIL3	chr2	201736043	-	NEMF	chr14	50065705	+
intron-intron	ENST00000286175	ENST00000545773	PPIL3	chr2	201736043	-	NEMF	chr14	50065705	+
intron-intron	ENST00000286175	ENST00000556925	PPIL3	chr2	201736043	-	NEMF	chr14	50065705	+
intron-intron	ENST00000286175	ENST00000546046	PPIL3	chr2	201736043	-	NEMF	chr14	50065705	+
intron-intron	ENST00000286175	ENST00000556672	PPIL3	chr2	201736043	-	NEMF	chr14	50065705	+
intron-intron	ENST00000392283	ENST00000298310	PPIL3	chr2	201736043	-	NEMF	chr14	50065705	+
intron-intron	ENST00000392283	ENST00000382135	PPIL3	chr2	201736043	-	NEMF	chr14	50065705	+
intron-intron	ENST00000392283	ENST00000545773	PPIL3	chr2	201736043	-	NEMF	chr14	50065705	+
intron-intron	ENST00000392283	ENST00000556925	PPIL3	chr2	201736043	-	NEMF	chr14	50065705	+
intron-intron	ENST00000392283	ENST00000546046	PPIL3	chr2	201736043	-	NEMF	chr14	50065705	+
intron-intron	ENST00000392283	ENST00000556672	PPIL3	chr2	201736043	-	NEMF	chr14	50065705	+
intron-intron	ENST00000465823	ENST00000298310	PPIL3	chr2	201736043	-	NEMF	chr14	50065705	+
intron-intron	ENST00000465823	ENST00000382135	PPIL3	chr2	201736043	-	NEMF	chr14	50065705	+
intron-intron	ENST00000465823	ENST00000545773	PPIL3	chr2	201736043	-	NEMF	chr14	50065705	+
intron-intron	ENST00000465823	ENST00000556925	PPIL3	chr2	201736043	-	NEMF	chr14	50065705	+
intron-intron	ENST00000465823	ENST00000546046	PPIL3	chr2	201736043	-	NEMF	chr14	50065705	+
intron-intron	ENST00000465823	ENST00000556672	PPIL3	chr2	201736043	-	NEMF	chr14	50065705	+
intron-intron	ENST00000409361	ENST00000298310	PPIL3	chr2	201736043	-	NEMF	chr14	50065705	+
intron-intron	ENST00000409361	ENST00000382135	PPIL3	chr2	201736043	-	NEMF	chr14	50065705	+
intron-intron	ENST00000409361	ENST00000545773	PPIL3	chr2	201736043	-	NEMF	chr14	50065705	+
intron-intron	ENST00000409361	ENST00000556925	PPIL3	chr2	201736043	-	NEMF	chr14	50065705	+
intron-intron	ENST00000409361	ENST00000546046	PPIL3	chr2	201736043	-	NEMF	chr14	50065705	+
intron-intron	ENST00000409361	ENST00000556672	PPIL3	chr2	201736043	-	NEMF	chr14	50065705	+
intron-intron	ENST00000409449	ENST00000298310	PPIL3	chr2	201736043	-	NEMF	chr14	50065705	+
intron-intron	ENST00000409449	ENST00000382135	PPIL3	chr2	201736043	-	NEMF	chr14	50065705	+
intron-intron	ENST00000409449	ENST00000545773	PPIL3	chr2	201736043	-	NEMF	chr14	50065705	+
intron-intron	ENST00000409449	ENST00000556925	PPIL3	chr2	201736043	-	NEMF	chr14	50065705	+
intron-intron	ENST00000409449	ENST00000546046	PPIL3	chr2	201736043	-	NEMF	chr14	50065705	+
intron-intron	ENST00000409449	ENST00000556672	PPIL3	chr2	201736043	-	NEMF	chr14	50065705	+

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FusionProtFeatures for PPIL3_NEMF

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
PPIL3 Q9H2H8	NEMF O60524

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Fusion gene ID: 28211

FusionGeneSummary for PPIL3_NEMF

FusionProtFeatures for PPIL3_NEMF