|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 28175 |
FusionGeneSummary for PPFIBP1_PDILT |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPFIBP1_PDILT | Fusion gene ID: 28175 | Hgene | Tgene | Gene symbol | PPFIBP1 | PDILT | Gene ID | 8496 | 204474 |
| Gene name | PPFIA binding protein 1 | protein disulfide isomerase like, testis expressed | |
| Synonyms | L2|SGT2|hSGT2|hSgt2p | PDIA7 | |
| Cytomap | 12p11.23-p11.22 | 16p12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | liprin-beta-1PTPRF interacting protein, binding protein 1 (liprin beta 1)PTPRF-interacting protein-binding protein 1liprin related proteinprotein-tyrosine phosphatase receptor-type f polypeptide-interacting protein-binding protein 1 | protein disulfide-isomerase-like protein of the testisprotein disulfide isomerase family A, member 7 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q86W92 | Q8N807 | |
| Ensembl transtripts involved in fusion gene | ENST00000545334, ENST00000537927, ENST00000318304, ENST00000535047, ENST00000542629, ENST00000228425, ENST00000541633, | ENST00000302451, | |
| Fusion gene scores | * DoF score | 10 X 6 X 8=480 | 2 X 2 X 2=8 |
| # samples | 11 | 2 | |
| ** MAII score | log2(11/480*10)=-2.12553088208386 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: PPFIBP1 [Title/Abstract] AND PDILT [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-E2-A15A-06A | PPFIBP1 | chr12 | 27731172 | + | PDILT | chr16 | 20381011 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000545334 | ENST00000302451 | PPFIBP1 | chr12 | 27731172 | + | PDILT | chr16 | 20381011 | - |
| 5UTR-3CDS | ENST00000537927 | ENST00000302451 | PPFIBP1 | chr12 | 27731172 | + | PDILT | chr16 | 20381011 | - |
| 5UTR-3CDS | ENST00000318304 | ENST00000302451 | PPFIBP1 | chr12 | 27731172 | + | PDILT | chr16 | 20381011 | - |
| 5UTR-3CDS | ENST00000535047 | ENST00000302451 | PPFIBP1 | chr12 | 27731172 | + | PDILT | chr16 | 20381011 | - |
| 5UTR-3CDS | ENST00000542629 | ENST00000302451 | PPFIBP1 | chr12 | 27731172 | + | PDILT | chr16 | 20381011 | - |
| 5UTR-3CDS | ENST00000228425 | ENST00000302451 | PPFIBP1 | chr12 | 27731172 | + | PDILT | chr16 | 20381011 | - |
| 3UTR-3CDS | ENST00000541633 | ENST00000302451 | PPFIBP1 | chr12 | 27731172 | + | PDILT | chr16 | 20381011 | - |
Top |
FusionProtFeatures for PPFIBP1_PDILT |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPFIBP1 | PDILT |