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Fusion gene ID: 28128 |
FusionGeneSummary for PPFIA1_CD82 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPFIA1_CD82 | Fusion gene ID: 28128 | Hgene | Tgene | Gene symbol | PPFIA1 | CD82 | Gene ID | 8500 | 3732 |
| Gene name | PTPRF interacting protein alpha 1 | CD82 molecule | |
| Synonyms | LIP.1|LIP1|LIPRIN | 4F9|C33|GR15|IA4|KAI1|R2|SAR2|ST6|TSPAN27 | |
| Cytomap | 11q13.3 | 11p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | liprin-alpha-1LAR-interacting protein 1LIP-1Liprin-alpha1protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | CD82 antigenC33 antigeninducible membrane protein R2kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4))metastasis suppressor Kangai-1tetraspanin-27tspan-27 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q13136 | P27701 | |
| Ensembl transtripts involved in fusion gene | ENST00000253925, ENST00000389547, ENST00000530548, | ENST00000227155, ENST00000342935, ENST00000530931, | |
| Fusion gene scores | * DoF score | 36 X 13 X 14=6552 | 5 X 3 X 4=60 |
| # samples | 41 | 5 | |
| ** MAII score | log2(41/6552*10)=-3.99823954213556 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PPFIA1 [Title/Abstract] AND CD82 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCEC | TCGA-B5-A5OD-01A | PPFIA1 | chr11 | 70118542 | + | CD82 | chr11 | 44609025 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000253925 | ENST00000227155 | PPFIA1 | chr11 | 70118542 | + | CD82 | chr11 | 44609025 | + |
| 5CDS-5UTR | ENST00000253925 | ENST00000342935 | PPFIA1 | chr11 | 70118542 | + | CD82 | chr11 | 44609025 | + |
| 5CDS-intron | ENST00000253925 | ENST00000530931 | PPFIA1 | chr11 | 70118542 | + | CD82 | chr11 | 44609025 | + |
| 5CDS-5UTR | ENST00000389547 | ENST00000227155 | PPFIA1 | chr11 | 70118542 | + | CD82 | chr11 | 44609025 | + |
| 5CDS-5UTR | ENST00000389547 | ENST00000342935 | PPFIA1 | chr11 | 70118542 | + | CD82 | chr11 | 44609025 | + |
| 5CDS-intron | ENST00000389547 | ENST00000530931 | PPFIA1 | chr11 | 70118542 | + | CD82 | chr11 | 44609025 | + |
| intron-5UTR | ENST00000530548 | ENST00000227155 | PPFIA1 | chr11 | 70118542 | + | CD82 | chr11 | 44609025 | + |
| intron-5UTR | ENST00000530548 | ENST00000342935 | PPFIA1 | chr11 | 70118542 | + | CD82 | chr11 | 44609025 | + |
| intron-intron | ENST00000530548 | ENST00000530931 | PPFIA1 | chr11 | 70118542 | + | CD82 | chr11 | 44609025 | + |
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FusionProtFeatures for PPFIA1_CD82 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPFIA1 | CD82 |