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Fusion gene ID: 28066 |
FusionGeneSummary for PPA1_LRRC20 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PPA1_LRRC20 | Fusion gene ID: 28066 | Hgene | Tgene | Gene symbol | PPA1 | LRRC20 | Gene ID | 5464 | 55222 |
| Gene name | pyrophosphatase (inorganic) 1 | leucine rich repeat containing 20 | |
| Synonyms | HEL-S-66p|IOPPP|PP|PP1|SID6-8061 | - | |
| Cytomap | 10q22.1 | 10q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | inorganic pyrophosphatasePPasecytosolic inorganic pyrophosphatasediphosphate phosphohydrolaseepididymis secretory sperm binding protein Li 66pinorganic diphosphatase 1inorganic pyrophosphatase 1pyrophosphatase 1pyrophosphate phospho-hydrolase | leucine-rich repeat-containing protein 20 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q15181 | Q8TCA0 | |
| Ensembl transtripts involved in fusion gene | ENST00000373232, ENST00000608321, ENST00000495346, | ENST00000395011, ENST00000395010, ENST00000355790, ENST00000373224, ENST00000358141, | |
| Fusion gene scores | * DoF score | 5 X 4 X 3=60 | 2 X 1 X 2=4 |
| # samples | 6 | 2 | |
| ** MAII score | log2(6/60*10)=0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: PPA1 [Title/Abstract] AND LRRC20 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-JL-A3YW-01A | PPA1 | chr10 | 71977568 | - | LRRC20 | chr10 | 72083786 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000373232 | ENST00000395011 | PPA1 | chr10 | 71977568 | - | LRRC20 | chr10 | 72083786 | - |
| 5CDS-intron | ENST00000373232 | ENST00000395010 | PPA1 | chr10 | 71977568 | - | LRRC20 | chr10 | 72083786 | - |
| 5CDS-intron | ENST00000373232 | ENST00000355790 | PPA1 | chr10 | 71977568 | - | LRRC20 | chr10 | 72083786 | - |
| 5CDS-intron | ENST00000373232 | ENST00000373224 | PPA1 | chr10 | 71977568 | - | LRRC20 | chr10 | 72083786 | - |
| 5CDS-intron | ENST00000373232 | ENST00000358141 | PPA1 | chr10 | 71977568 | - | LRRC20 | chr10 | 72083786 | - |
| Frame-shift | ENST00000608321 | ENST00000395011 | PPA1 | chr10 | 71977568 | - | LRRC20 | chr10 | 72083786 | - |
| 5CDS-intron | ENST00000608321 | ENST00000395010 | PPA1 | chr10 | 71977568 | - | LRRC20 | chr10 | 72083786 | - |
| 5CDS-intron | ENST00000608321 | ENST00000355790 | PPA1 | chr10 | 71977568 | - | LRRC20 | chr10 | 72083786 | - |
| 5CDS-intron | ENST00000608321 | ENST00000373224 | PPA1 | chr10 | 71977568 | - | LRRC20 | chr10 | 72083786 | - |
| 5CDS-intron | ENST00000608321 | ENST00000358141 | PPA1 | chr10 | 71977568 | - | LRRC20 | chr10 | 72083786 | - |
| intron-3CDS | ENST00000495346 | ENST00000395011 | PPA1 | chr10 | 71977568 | - | LRRC20 | chr10 | 72083786 | - |
| intron-intron | ENST00000495346 | ENST00000395010 | PPA1 | chr10 | 71977568 | - | LRRC20 | chr10 | 72083786 | - |
| intron-intron | ENST00000495346 | ENST00000355790 | PPA1 | chr10 | 71977568 | - | LRRC20 | chr10 | 72083786 | - |
| intron-intron | ENST00000495346 | ENST00000373224 | PPA1 | chr10 | 71977568 | - | LRRC20 | chr10 | 72083786 | - |
| intron-intron | ENST00000495346 | ENST00000358141 | PPA1 | chr10 | 71977568 | - | LRRC20 | chr10 | 72083786 | - |
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FusionProtFeatures for PPA1_LRRC20 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PPA1 | LRRC20 |