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Fusion gene ID: 28062 |
FusionGeneSummary for POU6F2_AOAH |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: POU6F2_AOAH | Fusion gene ID: 28062 | Hgene | Tgene | Gene symbol | POU6F2 | AOAH | Gene ID | 11281 | 313 |
| Gene name | POU class 6 homeobox 2 | acyloxyacyl hydrolase | |
| Synonyms | RPF-1|WT5|WTSL | - | |
| Cytomap | 7p14.1 | 7p14.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | POU domain, class 6, transcription factor 2Wilms tumor suppressor locusretina-derived POU-domain factor-1 | acyloxyacyl hydrolaseacyloxyacyl hydrolase (neutrophil) | |
| Modification date | 20180403 | 20180523 | |
| UniProtAcc | P78424 | P28039 | |
| Ensembl transtripts involved in fusion gene | ENST00000403058, ENST00000518318, ENST00000517348, ENST00000559001, ENST00000464276, | ENST00000535891, ENST00000258749, ENST00000431169, ENST00000538464, ENST00000491444, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 6 X 6 X 4=144 |
| # samples | 3 | 7 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/144*10)=-1.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: POU6F2 [Title/Abstract] AND AOAH [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | AOAH | GO:0006631 | fatty acid metabolic process | 1883828|29343645 |
| Tgene | AOAH | GO:0009104 | lipopolysaccharide catabolic process | 1883828|29343645 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | GBM | TCGA-26-A7UX-01B | POU6F2 | chr7 | 39503983 | + | AOAH | chr7 | 36571950 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000403058 | ENST00000535891 | POU6F2 | chr7 | 39503983 | + | AOAH | chr7 | 36571950 | - |
| Frame-shift | ENST00000403058 | ENST00000258749 | POU6F2 | chr7 | 39503983 | + | AOAH | chr7 | 36571950 | - |
| Frame-shift | ENST00000403058 | ENST00000431169 | POU6F2 | chr7 | 39503983 | + | AOAH | chr7 | 36571950 | - |
| Frame-shift | ENST00000403058 | ENST00000538464 | POU6F2 | chr7 | 39503983 | + | AOAH | chr7 | 36571950 | - |
| 5CDS-5UTR | ENST00000403058 | ENST00000491444 | POU6F2 | chr7 | 39503983 | + | AOAH | chr7 | 36571950 | - |
| Frame-shift | ENST00000518318 | ENST00000535891 | POU6F2 | chr7 | 39503983 | + | AOAH | chr7 | 36571950 | - |
| Frame-shift | ENST00000518318 | ENST00000258749 | POU6F2 | chr7 | 39503983 | + | AOAH | chr7 | 36571950 | - |
| Frame-shift | ENST00000518318 | ENST00000431169 | POU6F2 | chr7 | 39503983 | + | AOAH | chr7 | 36571950 | - |
| Frame-shift | ENST00000518318 | ENST00000538464 | POU6F2 | chr7 | 39503983 | + | AOAH | chr7 | 36571950 | - |
| 5CDS-5UTR | ENST00000518318 | ENST00000491444 | POU6F2 | chr7 | 39503983 | + | AOAH | chr7 | 36571950 | - |
| intron-3CDS | ENST00000517348 | ENST00000535891 | POU6F2 | chr7 | 39503983 | + | AOAH | chr7 | 36571950 | - |
| intron-3CDS | ENST00000517348 | ENST00000258749 | POU6F2 | chr7 | 39503983 | + | AOAH | chr7 | 36571950 | - |
| intron-3CDS | ENST00000517348 | ENST00000431169 | POU6F2 | chr7 | 39503983 | + | AOAH | chr7 | 36571950 | - |
| intron-3CDS | ENST00000517348 | ENST00000538464 | POU6F2 | chr7 | 39503983 | + | AOAH | chr7 | 36571950 | - |
| intron-5UTR | ENST00000517348 | ENST00000491444 | POU6F2 | chr7 | 39503983 | + | AOAH | chr7 | 36571950 | - |
| Frame-shift | ENST00000559001 | ENST00000535891 | POU6F2 | chr7 | 39503983 | + | AOAH | chr7 | 36571950 | - |
| Frame-shift | ENST00000559001 | ENST00000258749 | POU6F2 | chr7 | 39503983 | + | AOAH | chr7 | 36571950 | - |
| Frame-shift | ENST00000559001 | ENST00000431169 | POU6F2 | chr7 | 39503983 | + | AOAH | chr7 | 36571950 | - |
| Frame-shift | ENST00000559001 | ENST00000538464 | POU6F2 | chr7 | 39503983 | + | AOAH | chr7 | 36571950 | - |
| 5CDS-5UTR | ENST00000559001 | ENST00000491444 | POU6F2 | chr7 | 39503983 | + | AOAH | chr7 | 36571950 | - |
| intron-3CDS | ENST00000464276 | ENST00000535891 | POU6F2 | chr7 | 39503983 | + | AOAH | chr7 | 36571950 | - |
| intron-3CDS | ENST00000464276 | ENST00000258749 | POU6F2 | chr7 | 39503983 | + | AOAH | chr7 | 36571950 | - |
| intron-3CDS | ENST00000464276 | ENST00000431169 | POU6F2 | chr7 | 39503983 | + | AOAH | chr7 | 36571950 | - |
| intron-3CDS | ENST00000464276 | ENST00000538464 | POU6F2 | chr7 | 39503983 | + | AOAH | chr7 | 36571950 | - |
| intron-5UTR | ENST00000464276 | ENST00000491444 | POU6F2 | chr7 | 39503983 | + | AOAH | chr7 | 36571950 | - |
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FusionProtFeatures for POU6F2_AOAH |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| POU6F2 | AOAH |