|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 28042 |
FusionGeneSummary for POSTN_COL1A2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: POSTN_COL1A2 | Fusion gene ID: 28042 | Hgene | Tgene | Gene symbol | POSTN | COL1A2 | Gene ID | 10631 | 1278 |
| Gene name | periostin | collagen type I alpha 2 chain | |
| Synonyms | OSF-2|OSF2|PDLPOSTN|PN | EDSARTH2|EDSCV|OI4 | |
| Cytomap | 13q13.3 | 7q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | periostinosteoblast specific factor 2 (fasciclin I-like)periodontal ligament-specific periostinperiostin, osteoblast specific factor | collagen alpha-2(I) chainalpha 2 type I procollagenalpha 2(I) procollagenalpha 2(I)-collagenalpha-2 type I collagencollagen I, alpha-2 polypeptidecollagen of skin, tendon and bone, alpha-2 chaincollagen, type I, alpha 2type I procollagen | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q15063 | P08123 | |
| Ensembl transtripts involved in fusion gene | ENST00000541179, ENST00000379749, ENST00000379747, ENST00000379743, ENST00000379742, ENST00000541481, ENST00000497145, | ENST00000297268, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 17 X 22 X 6=2244 |
| # samples | 4 | 22 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(22/2244*10)=-3.35049724708413 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: POSTN [Title/Abstract] AND COL1A2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | POSTN | GO:0007155 | cell adhesion | 12235007 |
| Hgene | POSTN | GO:0071307 | cellular response to vitamin K | 18450759 |
| Tgene | COL1A2 | GO:0007179 | transforming growth factor beta receptor signaling pathway | 17217948 |
| Tgene | COL1A2 | GO:0007266 | Rho protein signal transduction | 17217948 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-E9-A1NF-01A | POSTN | chr13 | 38164509 | - | COL1A2 | chr7 | 94048810 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000541179 | ENST00000297268 | POSTN | chr13 | 38164509 | - | COL1A2 | chr7 | 94048810 | + |
| In-frame | ENST00000379749 | ENST00000297268 | POSTN | chr13 | 38164509 | - | COL1A2 | chr7 | 94048810 | + |
| In-frame | ENST00000379747 | ENST00000297268 | POSTN | chr13 | 38164509 | - | COL1A2 | chr7 | 94048810 | + |
| In-frame | ENST00000379743 | ENST00000297268 | POSTN | chr13 | 38164509 | - | COL1A2 | chr7 | 94048810 | + |
| In-frame | ENST00000379742 | ENST00000297268 | POSTN | chr13 | 38164509 | - | COL1A2 | chr7 | 94048810 | + |
| In-frame | ENST00000541481 | ENST00000297268 | POSTN | chr13 | 38164509 | - | COL1A2 | chr7 | 94048810 | + |
| intron-3CDS | ENST00000497145 | ENST00000297268 | POSTN | chr13 | 38164509 | - | COL1A2 | chr7 | 94048810 | + |
Top |
FusionProtFeatures for POSTN_COL1A2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| POSTN | COL1A2 |