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Fusion gene ID: 28023 |
FusionGeneSummary for POMK_NKAIN3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: POMK_NKAIN3 | Fusion gene ID: 28023 | Hgene | Tgene | Gene symbol | POMK | NKAIN3 | Gene ID | 84197 | 286183 |
| Gene name | protein-O-mannose kinase | sodium/potassium transporting ATPase interacting 3 | |
| Synonyms | MDDGA12|MDDGC12|SGK196 | FAM77D | |
| Cytomap | 8p11.21 | 8q12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein O-mannose kinaseSugen kinase 196probable inactive protein kinase-like protein SgK196protein kinase-like protein SgK196 | sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 3Na+/K+ transporting ATPase interacting 3family with sequence similarity 77, member D | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9H5K3 | Q8N8D7 | |
| Ensembl transtripts involved in fusion gene | ENST00000331373, | ENST00000519049, ENST00000523211, ENST00000328472, | |
| Fusion gene scores | * DoF score | 6 X 2 X 6=72 | 8 X 4 X 4=128 |
| # samples | 6 | 8 | |
| ** MAII score | log2(6/72*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/128*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: POMK [Title/Abstract] AND NKAIN3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | POMK | GO:0006493 | protein O-linked glycosylation | 23929950 |
| Hgene | POMK | GO:0046835 | carbohydrate phosphorylation | 23929950 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-BH-A18T-01A | POMK | chr8 | 42958973 | + | NKAIN3 | chr8 | 63492098 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000331373 | ENST00000519049 | POMK | chr8 | 42958973 | + | NKAIN3 | chr8 | 63492098 | + |
| 5CDS-3UTR | ENST00000331373 | ENST00000523211 | POMK | chr8 | 42958973 | + | NKAIN3 | chr8 | 63492098 | + |
| 5CDS-3UTR | ENST00000331373 | ENST00000328472 | POMK | chr8 | 42958973 | + | NKAIN3 | chr8 | 63492098 | + |
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FusionProtFeatures for POMK_NKAIN3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| POMK | NKAIN3 |