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Fusion gene ID: 27985 |
FusionGeneSummary for POLR2J3_LGALS4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: POLR2J3_LGALS4 | Fusion gene ID: 27985 | Hgene | Tgene | Gene symbol | POLR2J3 | LGALS4 | Gene ID | 548644 | 3960 |
| Gene name | RNA polymerase II subunit J3 | galectin 4 | |
| Synonyms | POLR2J2|RPB11b1|RPB11b2 | GAL4|L36LBP | |
| Cytomap | 7q22.1 | 19q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA-directed RNA polymerase II subunit RPB11-b2DNA-directed RNA polymerase II subunit 11DNA-directed RNA polymerase II subunit J3RNA polymerase II subunit B11-b2polymerase (RNA) II (DNA directed) polypeptide J3polymerase (RNA) II subunit J3 | galectin-4L-36 lactose-binding proteinantigen NY-CO-27gal-4lactose-binding lectin 4lectin, galactoside-binding, soluble, 4 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9H1A7 | P56470 | |
| Ensembl transtripts involved in fusion gene | ENST00000379357, ENST00000511313, ENST00000504157, ENST00000513438, | ENST00000307751, ENST00000597803, | |
| Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 5 X 4 X 4=80 |
| # samples | 2 | 5 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: POLR2J3 [Title/Abstract] AND LGALS4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-KK-A7B4-01A | POLR2J3 | chr7 | 102207444 | - | LGALS4 | chr19 | 39297235 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000379357 | ENST00000307751 | POLR2J3 | chr7 | 102207444 | - | LGALS4 | chr19 | 39297235 | - |
| intron-5UTR | ENST00000379357 | ENST00000597803 | POLR2J3 | chr7 | 102207444 | - | LGALS4 | chr19 | 39297235 | - |
| intron-3CDS | ENST00000511313 | ENST00000307751 | POLR2J3 | chr7 | 102207444 | - | LGALS4 | chr19 | 39297235 | - |
| intron-5UTR | ENST00000511313 | ENST00000597803 | POLR2J3 | chr7 | 102207444 | - | LGALS4 | chr19 | 39297235 | - |
| intron-3CDS | ENST00000504157 | ENST00000307751 | POLR2J3 | chr7 | 102207444 | - | LGALS4 | chr19 | 39297235 | - |
| intron-5UTR | ENST00000504157 | ENST00000597803 | POLR2J3 | chr7 | 102207444 | - | LGALS4 | chr19 | 39297235 | - |
| intron-3CDS | ENST00000513438 | ENST00000307751 | POLR2J3 | chr7 | 102207444 | - | LGALS4 | chr19 | 39297235 | - |
| intron-5UTR | ENST00000513438 | ENST00000597803 | POLR2J3 | chr7 | 102207444 | - | LGALS4 | chr19 | 39297235 | - |
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FusionProtFeatures for POLR2J3_LGALS4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| POLR2J3 | LGALS4 |