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Fusion gene ID: 27980 |
FusionGeneSummary for POLR2H_DTX3L |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: POLR2H_DTX3L | Fusion gene ID: 27980 | Hgene | Tgene | Gene symbol | POLR2H | DTX3L | Gene ID | 5437 | 151636 |
| Gene name | RNA polymerase II subunit H | deltex E3 ubiquitin ligase 3L | |
| Synonyms | RPABC3|RPB17|RPB8 | BBAP|RNF143 | |
| Cytomap | 3q27.1 | 3q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DNA-directed RNA polymerases I, II, and III subunit RPABC3DNA-directed RNA polymerase II subunit HDNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptideRPB8 homologpolymerase (RNA) II (DNA directed) polypeptide Hpolymerase (RNA) II subunit | E3 ubiquitin-protein ligase DTX3LB-lymphoma- and BAL-associated proteinRING-type E3 ubiquitin transferase DTX3Ldeltex 3 like, E3 ubiquitin ligasedeltex 3-likerhysin-2rhysin2 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P52434 | Q8TDB6 | |
| Ensembl transtripts involved in fusion gene | ENST00000456318, ENST00000438240, ENST00000460083, ENST00000430783, ENST00000443489, ENST00000452961, ENST00000296223, ENST00000429568, | ENST00000296161, ENST00000383661, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 4 X 5 X 1=20 |
| # samples | 3 | 5 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/20*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: POLR2H [Title/Abstract] AND DTX3L [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | POLR2H | GO:0006366 | transcription by RNA polymerase II | 9852112 |
| Tgene | DTX3L | GO:0010390 | histone monoubiquitination | 19818714|28525742 |
| Tgene | DTX3L | GO:0070936 | protein K48-linked ubiquitination | 26479788 |
| Tgene | DTX3L | GO:1901666 | positive regulation of NAD+ ADP-ribosyltransferase activity | 28525742 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF001934 | POLR2H | chr3 | 184086046 | - | DTX3L | chr3 | 122292177 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000456318 | ENST00000296161 | POLR2H | chr3 | 184086046 | - | DTX3L | chr3 | 122292177 | - |
| 5CDS-intron | ENST00000456318 | ENST00000383661 | POLR2H | chr3 | 184086046 | - | DTX3L | chr3 | 122292177 | - |
| 5CDS-3UTR | ENST00000438240 | ENST00000296161 | POLR2H | chr3 | 184086046 | - | DTX3L | chr3 | 122292177 | - |
| 5CDS-intron | ENST00000438240 | ENST00000383661 | POLR2H | chr3 | 184086046 | - | DTX3L | chr3 | 122292177 | - |
| intron-3UTR | ENST00000460083 | ENST00000296161 | POLR2H | chr3 | 184086046 | - | DTX3L | chr3 | 122292177 | - |
| intron-intron | ENST00000460083 | ENST00000383661 | POLR2H | chr3 | 184086046 | - | DTX3L | chr3 | 122292177 | - |
| 5CDS-3UTR | ENST00000430783 | ENST00000296161 | POLR2H | chr3 | 184086046 | - | DTX3L | chr3 | 122292177 | - |
| 5CDS-intron | ENST00000430783 | ENST00000383661 | POLR2H | chr3 | 184086046 | - | DTX3L | chr3 | 122292177 | - |
| 5CDS-3UTR | ENST00000443489 | ENST00000296161 | POLR2H | chr3 | 184086046 | - | DTX3L | chr3 | 122292177 | - |
| 5CDS-intron | ENST00000443489 | ENST00000383661 | POLR2H | chr3 | 184086046 | - | DTX3L | chr3 | 122292177 | - |
| 5CDS-3UTR | ENST00000452961 | ENST00000296161 | POLR2H | chr3 | 184086046 | - | DTX3L | chr3 | 122292177 | - |
| 5CDS-intron | ENST00000452961 | ENST00000383661 | POLR2H | chr3 | 184086046 | - | DTX3L | chr3 | 122292177 | - |
| 5CDS-3UTR | ENST00000296223 | ENST00000296161 | POLR2H | chr3 | 184086046 | - | DTX3L | chr3 | 122292177 | - |
| 5CDS-intron | ENST00000296223 | ENST00000383661 | POLR2H | chr3 | 184086046 | - | DTX3L | chr3 | 122292177 | - |
| 5CDS-3UTR | ENST00000429568 | ENST00000296161 | POLR2H | chr3 | 184086046 | - | DTX3L | chr3 | 122292177 | - |
| 5CDS-intron | ENST00000429568 | ENST00000383661 | POLR2H | chr3 | 184086046 | - | DTX3L | chr3 | 122292177 | - |
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FusionProtFeatures for POLR2H_DTX3L |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| POLR2H | DTX3L |