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Fusion gene ID: 27922 |
FusionGeneSummary for POLDIP3_MED15 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: POLDIP3_MED15 | Fusion gene ID: 27922 | Hgene | Tgene | Gene symbol | POLDIP3 | MED15 | Gene ID | 84271 | 51586 |
| Gene name | DNA polymerase delta interacting protein 3 | mediator complex subunit 15 | |
| Synonyms | PDIP3|PDIP46|SKAR | ARC105|CAG7A|CTG7A|PCQAP|TIG-1|TIG1|TNRC7 | |
| Cytomap | 22q13.2 | 22q11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | polymerase delta-interacting protein 346 kDa DNA polymerase delta interaction proteinRNA-binding protein P46S6K1 Aly/REF-like targetpolymerase (DNA) delta interacting protein 3polymerase (DNA-directed), delta interacting protein 3 | mediator of RNA polymerase II transcription subunit 15CTG repeat protein 7aPC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated proteinPC2 glutamine/Q-rich-associated proteinPC2-glutamine-rich-associated proteinTPA inducible ge | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q9BY77 | Q96RN5 | |
| Ensembl transtripts involved in fusion gene | ENST00000348657, ENST00000252115, ENST00000339677, ENST00000451060, ENST00000491021, | ENST00000425759, ENST00000292733, ENST00000542773, ENST00000263205, ENST00000406969, ENST00000382974, ENST00000541476, ENST00000478831, | |
| Fusion gene scores | * DoF score | 6 X 6 X 5=180 | 13 X 9 X 7=819 |
| # samples | 7 | 15 | |
| ** MAII score | log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(15/819*10)=-2.44890095114513 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: POLDIP3 [Title/Abstract] AND MED15 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | POLDIP3 | GO:0016973 | poly(A)+ mRNA export from nucleus | 22928037 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-FS-A4F4-06A | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000348657 | ENST00000425759 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| In-frame | ENST00000348657 | ENST00000292733 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| 5CDS-intron | ENST00000348657 | ENST00000542773 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| 5CDS-intron | ENST00000348657 | ENST00000263205 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| 5CDS-intron | ENST00000348657 | ENST00000406969 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| 5CDS-intron | ENST00000348657 | ENST00000382974 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| 5CDS-intron | ENST00000348657 | ENST00000541476 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| 5CDS-intron | ENST00000348657 | ENST00000478831 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| In-frame | ENST00000252115 | ENST00000425759 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| In-frame | ENST00000252115 | ENST00000292733 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| 5CDS-intron | ENST00000252115 | ENST00000542773 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| 5CDS-intron | ENST00000252115 | ENST00000263205 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| 5CDS-intron | ENST00000252115 | ENST00000406969 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| 5CDS-intron | ENST00000252115 | ENST00000382974 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| 5CDS-intron | ENST00000252115 | ENST00000541476 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| 5CDS-intron | ENST00000252115 | ENST00000478831 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| In-frame | ENST00000339677 | ENST00000425759 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| In-frame | ENST00000339677 | ENST00000292733 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| 5CDS-intron | ENST00000339677 | ENST00000542773 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| 5CDS-intron | ENST00000339677 | ENST00000263205 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| 5CDS-intron | ENST00000339677 | ENST00000406969 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| 5CDS-intron | ENST00000339677 | ENST00000382974 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| 5CDS-intron | ENST00000339677 | ENST00000541476 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| 5CDS-intron | ENST00000339677 | ENST00000478831 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| 5UTR-3CDS | ENST00000451060 | ENST00000425759 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| 5UTR-3CDS | ENST00000451060 | ENST00000292733 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| 5UTR-intron | ENST00000451060 | ENST00000542773 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| 5UTR-intron | ENST00000451060 | ENST00000263205 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| 5UTR-intron | ENST00000451060 | ENST00000406969 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| 5UTR-intron | ENST00000451060 | ENST00000382974 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| 5UTR-intron | ENST00000451060 | ENST00000541476 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| 5UTR-intron | ENST00000451060 | ENST00000478831 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| 5UTR-3CDS | ENST00000491021 | ENST00000425759 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| 5UTR-3CDS | ENST00000491021 | ENST00000292733 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| 5UTR-intron | ENST00000491021 | ENST00000542773 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| 5UTR-intron | ENST00000491021 | ENST00000263205 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| 5UTR-intron | ENST00000491021 | ENST00000406969 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| 5UTR-intron | ENST00000491021 | ENST00000382974 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| 5UTR-intron | ENST00000491021 | ENST00000541476 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
| 5UTR-intron | ENST00000491021 | ENST00000478831 | POLDIP3 | chr22 | 42998776 | - | MED15 | chr22 | 20905723 | + |
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FusionProtFeatures for POLDIP3_MED15 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| POLDIP3 | MED15 |