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Fusion gene ID: 27884 |
FusionGeneSummary for POFUT1_ITCH |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: POFUT1_ITCH | Fusion gene ID: 27884 | Hgene | Tgene | Gene symbol | POFUT1 | ITCH | Gene ID | 23509 | 83737 |
| Gene name | protein O-fucosyltransferase 1 | itchy E3 ubiquitin protein ligase | |
| Synonyms | DDD2|FUT12|O-FUT|O-Fuc-T|O-FucT-1|OFUCT1 | ADMFD|AIF4|AIP4|NAPP1 | |
| Cytomap | 20q11.21 | 20q11.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | GDP-fucose protein O-fucosyltransferase 1o-fucosyltransferase proteinpeptide-O-fucosyltransferase 1 | E3 ubiquitin-protein ligase Itchy homologHECT-type E3 ubiquitin transferase Itchy homologNFE2-associated polypeptide 1atrophin-1 interacting protein 4itchy E3 ubiquitin protein ligase homolog | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9H488 | Q96J02 | |
| Ensembl transtripts involved in fusion gene | ENST00000375749, ENST00000375730, ENST00000539210, ENST00000486717, | ENST00000374864, ENST00000535650, ENST00000262650, ENST00000483727, | |
| Fusion gene scores | * DoF score | 7 X 5 X 6=210 | 8 X 8 X 5=320 |
| # samples | 9 | 9 | |
| ** MAII score | log2(9/210*10)=-1.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/320*10)=-1.83007499855769 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: POFUT1 [Title/Abstract] AND ITCH [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | POFUT1 | GO:0006493 | protein O-linked glycosylation | 9023546|11524432 |
| Hgene | POFUT1 | GO:0036066 | protein O-linked fucosylation | 15653671 |
| Tgene | ITCH | GO:0006511 | ubiquitin-dependent protein catabolic process | 15678106 |
| Tgene | ITCH | GO:0016567 | protein ubiquitination | 17592138|25631046 |
| Tgene | ITCH | GO:0035519 | protein K29-linked ubiquitination | 17028573|18628966 |
| Tgene | ITCH | GO:0070534 | protein K63-linked ubiquitination | 18718448|19592251 |
| Tgene | ITCH | GO:0070936 | protein K48-linked ubiquitination | 19881509 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-50-6590-01A | POFUT1 | chr20 | 30804524 | + | ITCH | chr20 | 33030013 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000375749 | ENST00000374864 | POFUT1 | chr20 | 30804524 | + | ITCH | chr20 | 33030013 | + |
| In-frame | ENST00000375749 | ENST00000535650 | POFUT1 | chr20 | 30804524 | + | ITCH | chr20 | 33030013 | + |
| In-frame | ENST00000375749 | ENST00000262650 | POFUT1 | chr20 | 30804524 | + | ITCH | chr20 | 33030013 | + |
| 5CDS-intron | ENST00000375749 | ENST00000483727 | POFUT1 | chr20 | 30804524 | + | ITCH | chr20 | 33030013 | + |
| In-frame | ENST00000375730 | ENST00000374864 | POFUT1 | chr20 | 30804524 | + | ITCH | chr20 | 33030013 | + |
| In-frame | ENST00000375730 | ENST00000535650 | POFUT1 | chr20 | 30804524 | + | ITCH | chr20 | 33030013 | + |
| In-frame | ENST00000375730 | ENST00000262650 | POFUT1 | chr20 | 30804524 | + | ITCH | chr20 | 33030013 | + |
| 5CDS-intron | ENST00000375730 | ENST00000483727 | POFUT1 | chr20 | 30804524 | + | ITCH | chr20 | 33030013 | + |
| intron-3CDS | ENST00000539210 | ENST00000374864 | POFUT1 | chr20 | 30804524 | + | ITCH | chr20 | 33030013 | + |
| intron-3CDS | ENST00000539210 | ENST00000535650 | POFUT1 | chr20 | 30804524 | + | ITCH | chr20 | 33030013 | + |
| intron-3CDS | ENST00000539210 | ENST00000262650 | POFUT1 | chr20 | 30804524 | + | ITCH | chr20 | 33030013 | + |
| intron-intron | ENST00000539210 | ENST00000483727 | POFUT1 | chr20 | 30804524 | + | ITCH | chr20 | 33030013 | + |
| 3UTR-3CDS | ENST00000486717 | ENST00000374864 | POFUT1 | chr20 | 30804524 | + | ITCH | chr20 | 33030013 | + |
| 3UTR-3CDS | ENST00000486717 | ENST00000535650 | POFUT1 | chr20 | 30804524 | + | ITCH | chr20 | 33030013 | + |
| 3UTR-3CDS | ENST00000486717 | ENST00000262650 | POFUT1 | chr20 | 30804524 | + | ITCH | chr20 | 33030013 | + |
| 3UTR-intron | ENST00000486717 | ENST00000483727 | POFUT1 | chr20 | 30804524 | + | ITCH | chr20 | 33030013 | + |
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FusionProtFeatures for POFUT1_ITCH |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| POFUT1 | ITCH |