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Fusion gene ID: 27866 |
FusionGeneSummary for PNP_RAB7A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PNP_RAB7A | Fusion gene ID: 27866 | Hgene | Tgene | Gene symbol | PNP | RAB7A | Gene ID | 5539 | 7879 |
| Gene name | pancreatic polypeptide | RAB7A, member RAS oncogene family | |
| Synonyms | PNP|PP | PRO2706|RAB7 | |
| Cytomap | 17q21.31 | 3q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | pancreatic prohormonepancreatic polypeptide Yprepro-PP (prepropancreatic polypeptide) | ras-related protein Rab-7aRAB7, member RAS oncogene familyRas-associated protein RAB7 | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | P00491 | P51149 | |
| Ensembl transtripts involved in fusion gene | ENST00000361505, | ENST00000265062, ENST00000482525, ENST00000485280, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 11 X 9 X 5=495 |
| # samples | 1 | 12 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(12/495*10)=-2.04439411935845 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PNP [Title/Abstract] AND RAB7A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | RAB7A | GO:0022615 | protein to membrane docking | 24344282 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BQ315891 | PNP | chr14 | 20944895 | - | RAB7A | chr3 | 128516859 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000361505 | ENST00000265062 | PNP | chr14 | 20944895 | - | RAB7A | chr3 | 128516859 | + |
| 3UTR-3CDS | ENST00000361505 | ENST00000482525 | PNP | chr14 | 20944895 | - | RAB7A | chr3 | 128516859 | + |
| 3UTR-3CDS | ENST00000361505 | ENST00000485280 | PNP | chr14 | 20944895 | - | RAB7A | chr3 | 128516859 | + |
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FusionProtFeatures for PNP_RAB7A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PNP | RAB7A |