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Fusion gene ID: 2785 |
FusionGeneSummary for ARNT2_TNFAIP8L3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ARNT2_TNFAIP8L3 | Fusion gene ID: 2785 | Hgene | Tgene | Gene symbol | ARNT2 | TNFAIP8L3 | Gene ID | 9915 | 388121 |
| Gene name | aryl hydrocarbon receptor nuclear translocator 2 | TNF alpha induced protein 8 like 3 | |
| Synonyms | WEDAS|bHLHe1 | TIPE3 | |
| Cytomap | 15q25.1 | 15q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | aryl hydrocarbon receptor nuclear translocator 2ARNT protein 2class E basic helix-loop-helix protein 1 | tumor necrosis factor alpha-induced protein 8-like protein 3TNF alpha-induced protein 8-like protein 3TNFAIP8-like protein 3tumor necrosis factor, alpha induced protein 8 like 3 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9HBZ2 | Q5GJ75 | |
| Ensembl transtripts involved in fusion gene | ENST00000303329, ENST00000533983, ENST00000527771, ENST00000531595, | ENST00000327536, | |
| Fusion gene scores | * DoF score | 7 X 5 X 5=175 | 3 X 1 X 3=9 |
| # samples | 7 | 3 | |
| ** MAII score | log2(7/175*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: ARNT2 [Title/Abstract] AND TNFAIP8L3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ARNT2 | GO:0001666 | response to hypoxia | 12239177 |
| Hgene | ARNT2 | GO:0006355 | regulation of transcription, DNA-templated | 11782478 |
| Hgene | ARNT2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 24465693 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | KIRC | TCGA-BP-5169-01A | ARNT2 | chr15 | 80750317 | + | TNFAIP8L3 | chr15 | 51350640 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000303329 | ENST00000327536 | ARNT2 | chr15 | 80750317 | + | TNFAIP8L3 | chr15 | 51350640 | - |
| Frame-shift | ENST00000533983 | ENST00000327536 | ARNT2 | chr15 | 80750317 | + | TNFAIP8L3 | chr15 | 51350640 | - |
| Frame-shift | ENST00000527771 | ENST00000327536 | ARNT2 | chr15 | 80750317 | + | TNFAIP8L3 | chr15 | 51350640 | - |
| intron-3CDS | ENST00000531595 | ENST00000327536 | ARNT2 | chr15 | 80750317 | + | TNFAIP8L3 | chr15 | 51350640 | - |
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FusionProtFeatures for ARNT2_TNFAIP8L3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ARNT2 | TNFAIP8L3 |