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Fusion gene ID: 27830 |
FusionGeneSummary for PNLIP_CELA2A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PNLIP_CELA2A | Fusion gene ID: 27830 | Hgene | Tgene | Gene symbol | PNLIP | CELA2A | Gene ID | 5406 | 63036 |
| Gene name | pancreatic lipase | chymotrypsin like elastase family member 2A | |
| Synonyms | PL|PNLIPD|PTL | ELA2A|PE-1 | |
| Cytomap | 10q25.3 | 1p36.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | pancreatic triacylglycerol lipasetriacylglycerol acylhydrolase | chymotrypsin-like elastase family member 2Aelastase 2Apancreatic elastase 2pancreatic elastase IIA | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P16233 | P08217 | |
| Ensembl transtripts involved in fusion gene | ENST00000369221, ENST00000470562, | ENST00000359621, ENST00000497590, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 2 X 2 X 2=8 |
| # samples | 4 | 2 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: PNLIP [Title/Abstract] AND CELA2A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tissue-specifically expressed gene involved fusion gene, inframe and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PNLIP | GO:0061365 | positive regulation of triglyceride lipase activity | 9631512 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PAAD | TCGA-2J-AABV-01A | PNLIP | chr10 | 118310744 | + | CELA2A | chr1 | 15798485 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000369221 | ENST00000359621 | PNLIP | chr10 | 118310744 | + | CELA2A | chr1 | 15798485 | + |
| 5CDS-intron | ENST00000369221 | ENST00000497590 | PNLIP | chr10 | 118310744 | + | CELA2A | chr1 | 15798485 | + |
| 3UTR-3CDS | ENST00000470562 | ENST00000359621 | PNLIP | chr10 | 118310744 | + | CELA2A | chr1 | 15798485 | + |
| 3UTR-intron | ENST00000470562 | ENST00000497590 | PNLIP | chr10 | 118310744 | + | CELA2A | chr1 | 15798485 | + |
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FusionProtFeatures for PNLIP_CELA2A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PNLIP | CELA2A |