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Fusion gene ID: 27802 |
FusionGeneSummary for PMPCA_GATAD2A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PMPCA_GATAD2A | Fusion gene ID: 27802 | Hgene | Tgene | Gene symbol | PMPCA | GATAD2A | Gene ID | 23203 | 54815 |
| Gene name | peptidase, mitochondrial processing alpha subunit | GATA zinc finger domain containing 2A | |
| Synonyms | Alpha-MPP|CLA1|CPD3|INPP5E|P-55|SCAR2 | p66alpha | |
| Cytomap | 9q34.3 | 19p13.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mitochondrial-processing peptidase subunit alphaCerebellar ataxia-1cerebellar ataxia 1 (autosomal recessive)inositol polyphosphate-5-phosphatase, 72 kDmitochondrial matrix processing protease, alpha subunit | transcriptional repressor p66-alphaGATA zinc finger domain-containing protein 2A | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q10713 | Q86YP4 | |
| Ensembl transtripts involved in fusion gene | ENST00000371720, ENST00000371717, ENST00000399219, ENST00000462616, | ENST00000252577, ENST00000360315, ENST00000537887, ENST00000404158, ENST00000358713, ENST00000429563, ENST00000473184, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 8 X 7 X 7=392 |
| # samples | 2 | 9 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(9/392*10)=-2.12285674778553 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PMPCA [Title/Abstract] AND GATAD2A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | GATAD2A | GO:0045892 | negative regulation of transcription, DNA-templated | 12183469 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | M78956 | PMPCA | chr9 | 139317962 | - | GATAD2A | chr19 | 19619740 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000371720 | ENST00000252577 | PMPCA | chr9 | 139317962 | - | GATAD2A | chr19 | 19619740 | - |
| intron-intron | ENST00000371720 | ENST00000360315 | PMPCA | chr9 | 139317962 | - | GATAD2A | chr19 | 19619740 | - |
| intron-intron | ENST00000371720 | ENST00000537887 | PMPCA | chr9 | 139317962 | - | GATAD2A | chr19 | 19619740 | - |
| intron-intron | ENST00000371720 | ENST00000404158 | PMPCA | chr9 | 139317962 | - | GATAD2A | chr19 | 19619740 | - |
| intron-intron | ENST00000371720 | ENST00000358713 | PMPCA | chr9 | 139317962 | - | GATAD2A | chr19 | 19619740 | - |
| intron-intron | ENST00000371720 | ENST00000429563 | PMPCA | chr9 | 139317962 | - | GATAD2A | chr19 | 19619740 | - |
| intron-intron | ENST00000371720 | ENST00000473184 | PMPCA | chr9 | 139317962 | - | GATAD2A | chr19 | 19619740 | - |
| 3UTR-intron | ENST00000371717 | ENST00000252577 | PMPCA | chr9 | 139317962 | - | GATAD2A | chr19 | 19619740 | - |
| 3UTR-intron | ENST00000371717 | ENST00000360315 | PMPCA | chr9 | 139317962 | - | GATAD2A | chr19 | 19619740 | - |
| 3UTR-intron | ENST00000371717 | ENST00000537887 | PMPCA | chr9 | 139317962 | - | GATAD2A | chr19 | 19619740 | - |
| 3UTR-intron | ENST00000371717 | ENST00000404158 | PMPCA | chr9 | 139317962 | - | GATAD2A | chr19 | 19619740 | - |
| 3UTR-intron | ENST00000371717 | ENST00000358713 | PMPCA | chr9 | 139317962 | - | GATAD2A | chr19 | 19619740 | - |
| 3UTR-intron | ENST00000371717 | ENST00000429563 | PMPCA | chr9 | 139317962 | - | GATAD2A | chr19 | 19619740 | - |
| 3UTR-intron | ENST00000371717 | ENST00000473184 | PMPCA | chr9 | 139317962 | - | GATAD2A | chr19 | 19619740 | - |
| 3UTR-intron | ENST00000399219 | ENST00000252577 | PMPCA | chr9 | 139317962 | - | GATAD2A | chr19 | 19619740 | - |
| 3UTR-intron | ENST00000399219 | ENST00000360315 | PMPCA | chr9 | 139317962 | - | GATAD2A | chr19 | 19619740 | - |
| 3UTR-intron | ENST00000399219 | ENST00000537887 | PMPCA | chr9 | 139317962 | - | GATAD2A | chr19 | 19619740 | - |
| 3UTR-intron | ENST00000399219 | ENST00000404158 | PMPCA | chr9 | 139317962 | - | GATAD2A | chr19 | 19619740 | - |
| 3UTR-intron | ENST00000399219 | ENST00000358713 | PMPCA | chr9 | 139317962 | - | GATAD2A | chr19 | 19619740 | - |
| 3UTR-intron | ENST00000399219 | ENST00000429563 | PMPCA | chr9 | 139317962 | - | GATAD2A | chr19 | 19619740 | - |
| 3UTR-intron | ENST00000399219 | ENST00000473184 | PMPCA | chr9 | 139317962 | - | GATAD2A | chr19 | 19619740 | - |
| intron-intron | ENST00000462616 | ENST00000252577 | PMPCA | chr9 | 139317962 | - | GATAD2A | chr19 | 19619740 | - |
| intron-intron | ENST00000462616 | ENST00000360315 | PMPCA | chr9 | 139317962 | - | GATAD2A | chr19 | 19619740 | - |
| intron-intron | ENST00000462616 | ENST00000537887 | PMPCA | chr9 | 139317962 | - | GATAD2A | chr19 | 19619740 | - |
| intron-intron | ENST00000462616 | ENST00000404158 | PMPCA | chr9 | 139317962 | - | GATAD2A | chr19 | 19619740 | - |
| intron-intron | ENST00000462616 | ENST00000358713 | PMPCA | chr9 | 139317962 | - | GATAD2A | chr19 | 19619740 | - |
| intron-intron | ENST00000462616 | ENST00000429563 | PMPCA | chr9 | 139317962 | - | GATAD2A | chr19 | 19619740 | - |
| intron-intron | ENST00000462616 | ENST00000473184 | PMPCA | chr9 | 139317962 | - | GATAD2A | chr19 | 19619740 | - |
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FusionProtFeatures for PMPCA_GATAD2A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PMPCA | GATAD2A |