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Fusion gene ID: 27789 |
FusionGeneSummary for PML_AGBL3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PML_AGBL3 | Fusion gene ID: 27789 | Hgene | Tgene | Gene symbol | PML | AGBL3 | Gene ID | 5371 | 340351 |
| Gene name | promyelocytic leukemia | ATP/GTP binding protein like 3 | |
| Synonyms | MYL|PP8675|RNF71|TRIM19 | CCP3 | |
| Cytomap | 15q24.1 | 7q33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein PMLPML/RARA fusionRING finger protein 71probable transcription factor PMLpromyelocytic leukemia proteinpromyelocytic leukemia, inducer oftripartite motif protein TRIM19tripartite motif-containing protein 19 | cytosolic carboxypeptidase 3 | |
| Modification date | 20180523 | 20180403 | |
| UniProtAcc | P29590 | Q8NEM8 | |
| Ensembl transtripts involved in fusion gene | ENST00000395135, ENST00000395132, ENST00000268059, ENST00000354026, ENST00000268058, ENST00000565898, ENST00000569477, ENST00000569965, ENST00000567543, ENST00000435786, ENST00000436891, ENST00000564428, ENST00000359928, ENST00000563500, ENST00000569161, | ENST00000458078, ENST00000436302, ENST00000435976, ENST00000359383, ENST00000494702, | |
| Fusion gene scores | * DoF score | 5 X 10 X 4=200 | 2 X 1 X 2=4 |
| # samples | 27 | 2 | |
| ** MAII score | log2(27/200*10)=0.432959407276106 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: PML [Title/Abstract] AND AGBL3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PML | GO:0001666 | response to hypoxia | 16915281 |
| Hgene | PML | GO:0030308 | negative regulation of cell growth | 9448006 |
| Hgene | PML | GO:0034097 | response to cytokine | 9412458 |
| Hgene | PML | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 22406621 |
| Hgene | PML | GO:0045087 | innate immune response | 18248090 |
| Hgene | PML | GO:0045892 | negative regulation of transcription, DNA-templated | 9448006 |
| Hgene | PML | GO:0051457 | maintenance of protein location in nucleus | 17332504 |
| Hgene | PML | GO:0065003 | protein-containing complex assembly | 12915590 |
| Hgene | PML | GO:0090398 | cellular senescence | 22002537|22117195|23431171 |
| Hgene | PML | GO:1902187 | negative regulation of viral release from host cell | 18248090 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-20-1685-01A | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000395135 | ENST00000458078 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| Frame-shift | ENST00000395135 | ENST00000436302 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000395135 | ENST00000435976 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000395135 | ENST00000359383 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000395135 | ENST00000494702 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| Frame-shift | ENST00000395132 | ENST00000458078 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| Frame-shift | ENST00000395132 | ENST00000436302 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000395132 | ENST00000435976 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000395132 | ENST00000359383 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000395132 | ENST00000494702 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| Frame-shift | ENST00000268059 | ENST00000458078 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| Frame-shift | ENST00000268059 | ENST00000436302 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000268059 | ENST00000435976 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000268059 | ENST00000359383 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000268059 | ENST00000494702 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| Frame-shift | ENST00000354026 | ENST00000458078 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| Frame-shift | ENST00000354026 | ENST00000436302 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000354026 | ENST00000435976 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000354026 | ENST00000359383 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000354026 | ENST00000494702 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| Frame-shift | ENST00000268058 | ENST00000458078 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| Frame-shift | ENST00000268058 | ENST00000436302 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000268058 | ENST00000435976 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000268058 | ENST00000359383 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000268058 | ENST00000494702 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| Frame-shift | ENST00000565898 | ENST00000458078 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| Frame-shift | ENST00000565898 | ENST00000436302 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000565898 | ENST00000435976 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000565898 | ENST00000359383 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000565898 | ENST00000494702 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| Frame-shift | ENST00000569477 | ENST00000458078 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| Frame-shift | ENST00000569477 | ENST00000436302 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000569477 | ENST00000435976 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000569477 | ENST00000359383 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000569477 | ENST00000494702 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| Frame-shift | ENST00000569965 | ENST00000458078 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| Frame-shift | ENST00000569965 | ENST00000436302 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000569965 | ENST00000435976 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000569965 | ENST00000359383 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000569965 | ENST00000494702 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| Frame-shift | ENST00000567543 | ENST00000458078 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| Frame-shift | ENST00000567543 | ENST00000436302 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000567543 | ENST00000435976 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000567543 | ENST00000359383 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000567543 | ENST00000494702 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| Frame-shift | ENST00000435786 | ENST00000458078 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| Frame-shift | ENST00000435786 | ENST00000436302 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000435786 | ENST00000435976 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000435786 | ENST00000359383 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000435786 | ENST00000494702 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| Frame-shift | ENST00000436891 | ENST00000458078 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| Frame-shift | ENST00000436891 | ENST00000436302 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000436891 | ENST00000435976 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000436891 | ENST00000359383 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000436891 | ENST00000494702 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| Frame-shift | ENST00000564428 | ENST00000458078 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| Frame-shift | ENST00000564428 | ENST00000436302 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000564428 | ENST00000435976 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000564428 | ENST00000359383 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000564428 | ENST00000494702 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| Frame-shift | ENST00000359928 | ENST00000458078 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| Frame-shift | ENST00000359928 | ENST00000436302 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000359928 | ENST00000435976 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000359928 | ENST00000359383 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000359928 | ENST00000494702 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| Frame-shift | ENST00000563500 | ENST00000458078 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| Frame-shift | ENST00000563500 | ENST00000436302 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000563500 | ENST00000435976 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000563500 | ENST00000359383 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| 5CDS-intron | ENST00000563500 | ENST00000494702 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| intron-3CDS | ENST00000569161 | ENST00000458078 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| intron-3CDS | ENST00000569161 | ENST00000436302 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| intron-intron | ENST00000569161 | ENST00000435976 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| intron-intron | ENST00000569161 | ENST00000359383 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
| intron-intron | ENST00000569161 | ENST00000494702 | PML | chr15 | 74287282 | + | AGBL3 | chr7 | 134819593 | + |
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FusionProtFeatures for PML_AGBL3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PML | AGBL3 |