|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 27774 |
FusionGeneSummary for PLXND1_TMCC1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PLXND1_TMCC1 | Fusion gene ID: 27774 | Hgene | Tgene | Gene symbol | PLXND1 | TMCC1 | Gene ID | 23129 | 23023 |
| Gene name | plexin D1 | transmembrane and coiled-coil domain family 1 | |
| Synonyms | PLEXD1 | - | |
| Cytomap | 3q22.1 | 3q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | plexin-D1 | transmembrane and coiled-coil domains protein 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9Y4D7 | O94876 | |
| Ensembl transtripts involved in fusion gene | ENST00000324093, ENST00000393239, ENST00000504689, | ENST00000432054, ENST00000393238, ENST00000426664, ENST00000329333, ENST00000515024, | |
| Fusion gene scores | * DoF score | 5 X 5 X 3=75 | 5 X 5 X 5=125 |
| # samples | 5 | 7 | |
| ** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/125*10)=-0.836501267717121 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PLXND1 [Title/Abstract] AND TMCC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCEC | TCGA-AX-A2H4-01A | PLXND1 | chr3 | 129277271 | - | TMCC1 | chr3 | 129373946 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000324093 | ENST00000432054 | PLXND1 | chr3 | 129277271 | - | TMCC1 | chr3 | 129373946 | - |
| Frame-shift | ENST00000324093 | ENST00000393238 | PLXND1 | chr3 | 129277271 | - | TMCC1 | chr3 | 129373946 | - |
| Frame-shift | ENST00000324093 | ENST00000426664 | PLXND1 | chr3 | 129277271 | - | TMCC1 | chr3 | 129373946 | - |
| Frame-shift | ENST00000324093 | ENST00000329333 | PLXND1 | chr3 | 129277271 | - | TMCC1 | chr3 | 129373946 | - |
| 5CDS-intron | ENST00000324093 | ENST00000515024 | PLXND1 | chr3 | 129277271 | - | TMCC1 | chr3 | 129373946 | - |
| 3UTR-3CDS | ENST00000393239 | ENST00000432054 | PLXND1 | chr3 | 129277271 | - | TMCC1 | chr3 | 129373946 | - |
| 3UTR-3CDS | ENST00000393239 | ENST00000393238 | PLXND1 | chr3 | 129277271 | - | TMCC1 | chr3 | 129373946 | - |
| 3UTR-3CDS | ENST00000393239 | ENST00000426664 | PLXND1 | chr3 | 129277271 | - | TMCC1 | chr3 | 129373946 | - |
| 3UTR-3CDS | ENST00000393239 | ENST00000329333 | PLXND1 | chr3 | 129277271 | - | TMCC1 | chr3 | 129373946 | - |
| 3UTR-intron | ENST00000393239 | ENST00000515024 | PLXND1 | chr3 | 129277271 | - | TMCC1 | chr3 | 129373946 | - |
| intron-3CDS | ENST00000504689 | ENST00000432054 | PLXND1 | chr3 | 129277271 | - | TMCC1 | chr3 | 129373946 | - |
| intron-3CDS | ENST00000504689 | ENST00000393238 | PLXND1 | chr3 | 129277271 | - | TMCC1 | chr3 | 129373946 | - |
| intron-3CDS | ENST00000504689 | ENST00000426664 | PLXND1 | chr3 | 129277271 | - | TMCC1 | chr3 | 129373946 | - |
| intron-3CDS | ENST00000504689 | ENST00000329333 | PLXND1 | chr3 | 129277271 | - | TMCC1 | chr3 | 129373946 | - |
| intron-intron | ENST00000504689 | ENST00000515024 | PLXND1 | chr3 | 129277271 | - | TMCC1 | chr3 | 129373946 | - |
Top |
FusionProtFeatures for PLXND1_TMCC1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PLXND1 | TMCC1 |