|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 27763 |
FusionGeneSummary for PLXNB2_TRIM25 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PLXNB2_TRIM25 | Fusion gene ID: 27763 | Hgene | Tgene | Gene symbol | PLXNB2 | TRIM25 | Gene ID | 23654 | 7706 |
| Gene name | plexin B2 | tripartite motif containing 25 | |
| Synonyms | MM1|Nbla00445|PLEXB2|dJ402G11.3 | EFP|RNF147|Z147|ZNF147 | |
| Cytomap | 22q13.33 | 17q22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | plexin-B2 | E3 ubiquitin/ISG15 ligase TRIM25RING finger protein 147RING-type E3 ubiquitin transferaseRING-type E3 ubiquitin transferase TRIM25estrogen-responsive finger proteintripartite motif protein TRIM25tripartite motif-containing protein 25ubiquitin/ISG15 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | O15031 | Q14258 | |
| Ensembl transtripts involved in fusion gene | ENST00000359337, ENST00000449103, ENST00000496720, | ENST00000316881, ENST00000573108, ENST00000537230, | |
| Fusion gene scores | * DoF score | 14 X 12 X 9=1512 | 4 X 5 X 2=40 |
| # samples | 14 | 5 | |
| ** MAII score | log2(14/1512*10)=-3.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PLXNB2 [Title/Abstract] AND TRIM25 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PLXNB2 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | 16122393 |
| Hgene | PLXNB2 | GO:0010976 | positive regulation of neuron projection development | 16122393 |
| Tgene | TRIM25 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 23077300 |
| Tgene | TRIM25 | GO:0043627 | response to estrogen | 22452784 |
| Tgene | TRIM25 | GO:0045087 | innate immune response | 18248090 |
| Tgene | TRIM25 | GO:0046596 | regulation of viral entry into host cell | 18248090 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI492115 | PLXNB2 | chr22 | 50713479 | + | TRIM25 | chr17 | 54990919 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000359337 | ENST00000316881 | PLXNB2 | chr22 | 50713479 | + | TRIM25 | chr17 | 54990919 | + |
| intron-intron | ENST00000359337 | ENST00000573108 | PLXNB2 | chr22 | 50713479 | + | TRIM25 | chr17 | 54990919 | + |
| intron-intron | ENST00000359337 | ENST00000537230 | PLXNB2 | chr22 | 50713479 | + | TRIM25 | chr17 | 54990919 | + |
| intron-3CDS | ENST00000449103 | ENST00000316881 | PLXNB2 | chr22 | 50713479 | + | TRIM25 | chr17 | 54990919 | + |
| intron-intron | ENST00000449103 | ENST00000573108 | PLXNB2 | chr22 | 50713479 | + | TRIM25 | chr17 | 54990919 | + |
| intron-intron | ENST00000449103 | ENST00000537230 | PLXNB2 | chr22 | 50713479 | + | TRIM25 | chr17 | 54990919 | + |
| intron-3CDS | ENST00000496720 | ENST00000316881 | PLXNB2 | chr22 | 50713479 | + | TRIM25 | chr17 | 54990919 | + |
| intron-intron | ENST00000496720 | ENST00000573108 | PLXNB2 | chr22 | 50713479 | + | TRIM25 | chr17 | 54990919 | + |
| intron-intron | ENST00000496720 | ENST00000537230 | PLXNB2 | chr22 | 50713479 | + | TRIM25 | chr17 | 54990919 | + |
Top |
FusionProtFeatures for PLXNB2_TRIM25 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PLXNB2 | TRIM25 |