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Fusion gene ID: 27759 |
FusionGeneSummary for PLXNB2_SMPD4P1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PLXNB2_SMPD4P1 | Fusion gene ID: 27759 | Hgene | Tgene | Gene symbol | PLXNB2 | SMPD4P1 | Gene ID | 23654 | 645280 |
| Gene name | plexin B2 | sphingomyelin phosphodiesterase 4 pseudogene 1 | |
| Synonyms | MM1|Nbla00445|PLEXB2|dJ402G11.3 | - | |
| Cytomap | 22q13.33 | 22q11.21 | |
| Type of gene | protein-coding | pseudo | |
| Description | plexin-B2 | sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) pseudogene 1 | |
| Modification date | 20180523 | 20180329 | |
| UniProtAcc | O15031 | ||
| Ensembl transtripts involved in fusion gene | ENST00000359337, ENST00000449103, ENST00000496720, | ENST00000443839, | |
| Fusion gene scores | * DoF score | 14 X 12 X 9=1512 | 1 X 1 X 1=1 |
| # samples | 14 | 1 | |
| ** MAII score | log2(14/1512*10)=-3.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: PLXNB2 [Title/Abstract] AND SMPD4P1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PLXNB2 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | 16122393 |
| Hgene | PLXNB2 | GO:0010976 | positive regulation of neuron projection development | 16122393 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LGG | TCGA-TM-A84J-01A | PLXNB2 | chr22 | 50721766 | - | SMPD4P1 | chr22 | 20968022 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000359337 | ENST00000443839 | PLXNB2 | chr22 | 50721766 | - | SMPD4P1 | chr22 | 20968022 | - |
| 5CDS-intron | ENST00000449103 | ENST00000443839 | PLXNB2 | chr22 | 50721766 | - | SMPD4P1 | chr22 | 20968022 | - |
| 5CDS-intron | ENST00000496720 | ENST00000443839 | PLXNB2 | chr22 | 50721766 | - | SMPD4P1 | chr22 | 20968022 | - |
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FusionProtFeatures for PLXNB2_SMPD4P1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PLXNB2 | SMPD4P1 |