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Fusion gene ID: 27746 |
FusionGeneSummary for PLXNB1_HINT1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PLXNB1_HINT1 | Fusion gene ID: 27746 | Hgene | Tgene | Gene symbol | PLXNB1 | HINT1 | Gene ID | 5364 | 3094 |
| Gene name | plexin B1 | histidine triad nucleotide binding protein 1 | |
| Synonyms | PLEXIN-B1|PLXN5|SEP | HINT|NMAN|PKCI-1|PRKCNH1 | |
| Cytomap | 3p21.31 | 5q23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | plexin-B1plexin 5semaphorin receptor SEP | histidine triad nucleotide-binding protein 1adenosine 5'-monophosphoramidaseprotein kinase C inhibitor 1protein kinase C-interacting protein 1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | O43157 | P49773 | |
| Ensembl transtripts involved in fusion gene | ENST00000296440, ENST00000358459, ENST00000358536, ENST00000448774, ENST00000456774, ENST00000465117, | ENST00000304043, ENST00000506207, ENST00000508488, ENST00000506908, ENST00000513012, | |
| Fusion gene scores | * DoF score | 7 X 8 X 5=280 | 2 X 4 X 2=16 |
| # samples | 7 | 4 | |
| ** MAII score | log2(7/280*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PLXNB1 [Title/Abstract] AND HINT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PLXNB1 | GO:0007162 | negative regulation of cell adhesion | 15218527 |
| Hgene | PLXNB1 | GO:0008360 | regulation of cell shape | 19843518 |
| Hgene | PLXNB1 | GO:0051493 | regulation of cytoskeleton organization | 19843518 |
| Hgene | PLXNB1 | GO:0071526 | semaphorin-plexin signaling pathway | 15218527|19843518 |
| Tgene | HINT1 | GO:0009154 | purine ribonucleotide catabolic process | 16835243 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-E7-A5KE-01A | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000296440 | ENST00000304043 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
| 5CDS-intron | ENST00000296440 | ENST00000506207 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
| 5CDS-intron | ENST00000296440 | ENST00000508488 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
| 5CDS-intron | ENST00000296440 | ENST00000506908 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
| 5CDS-intron | ENST00000296440 | ENST00000513012 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
| 5CDS-intron | ENST00000358459 | ENST00000304043 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
| 5CDS-intron | ENST00000358459 | ENST00000506207 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
| 5CDS-intron | ENST00000358459 | ENST00000508488 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
| 5CDS-intron | ENST00000358459 | ENST00000506908 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
| 5CDS-intron | ENST00000358459 | ENST00000513012 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
| 5CDS-intron | ENST00000358536 | ENST00000304043 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
| 5CDS-intron | ENST00000358536 | ENST00000506207 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
| 5CDS-intron | ENST00000358536 | ENST00000508488 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
| 5CDS-intron | ENST00000358536 | ENST00000506908 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
| 5CDS-intron | ENST00000358536 | ENST00000513012 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
| 5CDS-intron | ENST00000448774 | ENST00000304043 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
| 5CDS-intron | ENST00000448774 | ENST00000506207 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
| 5CDS-intron | ENST00000448774 | ENST00000508488 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
| 5CDS-intron | ENST00000448774 | ENST00000506908 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
| 5CDS-intron | ENST00000448774 | ENST00000513012 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
| 5CDS-intron | ENST00000456774 | ENST00000304043 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
| 5CDS-intron | ENST00000456774 | ENST00000506207 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
| 5CDS-intron | ENST00000456774 | ENST00000508488 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
| 5CDS-intron | ENST00000456774 | ENST00000506908 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
| 5CDS-intron | ENST00000456774 | ENST00000513012 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
| intron-intron | ENST00000465117 | ENST00000304043 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
| intron-intron | ENST00000465117 | ENST00000506207 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
| intron-intron | ENST00000465117 | ENST00000508488 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
| intron-intron | ENST00000465117 | ENST00000506908 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
| intron-intron | ENST00000465117 | ENST00000513012 | PLXNB1 | chr3 | 48450979 | - | HINT1 | chr5 | 130507426 | - |
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FusionProtFeatures for PLXNB1_HINT1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PLXNB1 | HINT1 |