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Fusion gene ID: 27661

FusionGeneSummary for PLEKHJ1_TCF3

Fusion gene summary

Fusion gene information	Fusion gene name: PLEKHJ1_TCF3
	Fusion gene ID: 27661
		Hgene	Tgene
	Gene symbol	PLEKHJ1	TCF3
	Gene ID	55111	83439
	Gene name	pleckstrin homology domain containing J1	transcription factor 7 like 1
	Synonyms	GNRPX	TCF-3\|TCF3
	Cytomap	19p13.3	2p11.2
	Type of gene	protein-coding	protein-coding
	Description	pleckstrin homology domain-containing family J member 1PH domain-containing family J member 1guanine nucleotide releasing protein x	transcription factor 7-like 1HMG box transcription factor 3transcription factor 7-like 1 (T-cell specific, HMG-box)
	Modification date	20180523	20180523
	UniProtAcc	Q9NW61	P15923
	Ensembl transtripts involved in fusion gene	ENST00000587394, ENST00000587962, ENST00000586608, ENST00000589097, ENST00000591099, ENST00000326631, ENST00000589791,	ENST00000344749, ENST00000262965, ENST00000453954, ENST00000395423, ENST00000588136,
Fusion gene scores	* DoF score	5 X 4 X 3=60	7 X 9 X 3=189
	# samples	4	10
	** MAII score	log2(4/60*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/189*10)=-0.918386234446348 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PLEKHJ1 [Title/Abstract] AND TCF3 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	PRAD	TCGA-M7-A71Z-01A	PLEKHJ1	chr19	2235922	-	TCF3	chr19	1622414	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000587394	ENST00000344749	PLEKHJ1	chr19	2235922	-	TCF3	chr19	1622414	-
In-frame	ENST00000587394	ENST00000262965	PLEKHJ1	chr19	2235922	-	TCF3	chr19	1622414	-
In-frame	ENST00000587394	ENST00000453954	PLEKHJ1	chr19	2235922	-	TCF3	chr19	1622414	-
In-frame	ENST00000587394	ENST00000395423	PLEKHJ1	chr19	2235922	-	TCF3	chr19	1622414	-
In-frame	ENST00000587394	ENST00000588136	PLEKHJ1	chr19	2235922	-	TCF3	chr19	1622414	-
In-frame	ENST00000587962	ENST00000344749	PLEKHJ1	chr19	2235922	-	TCF3	chr19	1622414	-
In-frame	ENST00000587962	ENST00000262965	PLEKHJ1	chr19	2235922	-	TCF3	chr19	1622414	-
In-frame	ENST00000587962	ENST00000453954	PLEKHJ1	chr19	2235922	-	TCF3	chr19	1622414	-
In-frame	ENST00000587962	ENST00000395423	PLEKHJ1	chr19	2235922	-	TCF3	chr19	1622414	-
In-frame	ENST00000587962	ENST00000588136	PLEKHJ1	chr19	2235922	-	TCF3	chr19	1622414	-
intron-3CDS	ENST00000586608	ENST00000344749	PLEKHJ1	chr19	2235922	-	TCF3	chr19	1622414	-
intron-3CDS	ENST00000586608	ENST00000262965	PLEKHJ1	chr19	2235922	-	TCF3	chr19	1622414	-
intron-3CDS	ENST00000586608	ENST00000453954	PLEKHJ1	chr19	2235922	-	TCF3	chr19	1622414	-
intron-3CDS	ENST00000586608	ENST00000395423	PLEKHJ1	chr19	2235922	-	TCF3	chr19	1622414	-
intron-3CDS	ENST00000586608	ENST00000588136	PLEKHJ1	chr19	2235922	-	TCF3	chr19	1622414	-
In-frame	ENST00000589097	ENST00000344749	PLEKHJ1	chr19	2235922	-	TCF3	chr19	1622414	-
In-frame	ENST00000589097	ENST00000262965	PLEKHJ1	chr19	2235922	-	TCF3	chr19	1622414	-
In-frame	ENST00000589097	ENST00000453954	PLEKHJ1	chr19	2235922	-	TCF3	chr19	1622414	-
In-frame	ENST00000589097	ENST00000395423	PLEKHJ1	chr19	2235922	-	TCF3	chr19	1622414	-
In-frame	ENST00000589097	ENST00000588136	PLEKHJ1	chr19	2235922	-	TCF3	chr19	1622414	-
In-frame	ENST00000591099	ENST00000344749	PLEKHJ1	chr19	2235922	-	TCF3	chr19	1622414	-
In-frame	ENST00000591099	ENST00000262965	PLEKHJ1	chr19	2235922	-	TCF3	chr19	1622414	-
In-frame	ENST00000591099	ENST00000453954	PLEKHJ1	chr19	2235922	-	TCF3	chr19	1622414	-
In-frame	ENST00000591099	ENST00000395423	PLEKHJ1	chr19	2235922	-	TCF3	chr19	1622414	-
In-frame	ENST00000591099	ENST00000588136	PLEKHJ1	chr19	2235922	-	TCF3	chr19	1622414	-
In-frame	ENST00000326631	ENST00000344749	PLEKHJ1	chr19	2235922	-	TCF3	chr19	1622414	-
In-frame	ENST00000326631	ENST00000262965	PLEKHJ1	chr19	2235922	-	TCF3	chr19	1622414	-
In-frame	ENST00000326631	ENST00000453954	PLEKHJ1	chr19	2235922	-	TCF3	chr19	1622414	-
In-frame	ENST00000326631	ENST00000395423	PLEKHJ1	chr19	2235922	-	TCF3	chr19	1622414	-
In-frame	ENST00000326631	ENST00000588136	PLEKHJ1	chr19	2235922	-	TCF3	chr19	1622414	-
5UTR-3CDS	ENST00000589791	ENST00000344749	PLEKHJ1	chr19	2235922	-	TCF3	chr19	1622414	-
5UTR-3CDS	ENST00000589791	ENST00000262965	PLEKHJ1	chr19	2235922	-	TCF3	chr19	1622414	-
5UTR-3CDS	ENST00000589791	ENST00000453954	PLEKHJ1	chr19	2235922	-	TCF3	chr19	1622414	-
5UTR-3CDS	ENST00000589791	ENST00000395423	PLEKHJ1	chr19	2235922	-	TCF3	chr19	1622414	-
5UTR-3CDS	ENST00000589791	ENST00000588136	PLEKHJ1	chr19	2235922	-	TCF3	chr19	1622414	-

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FusionProtFeatures for PLEKHJ1_TCF3

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
PLEKHJ1 Q9NW61	TCF3 P15923

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Fusion gene ID: 27661

FusionGeneSummary for PLEKHJ1_TCF3

FusionProtFeatures for PLEKHJ1_TCF3