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Fusion gene ID: 27533 |
FusionGeneSummary for PLD2_SYTL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PLD2_SYTL1 | Fusion gene ID: 27533 | Hgene | Tgene | Gene symbol | PLD2 | SYTL1 | Gene ID | 5338 | 84958 |
| Gene name | phospholipase D2 | synaptotagmin like 1 | |
| Synonyms | PLD1C | JFC1|SLP1 | |
| Cytomap | 17p13.2 | 1p36.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | phospholipase D2choline phosphatase 2phosphatidylcholine-hydrolyzing phospholipase D2 | synaptotagmin-like protein 1NADPH oxidase-related, C2 domain-containing proteinexophilin-7 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O14939 | Q8IYJ3 | |
| Ensembl transtripts involved in fusion gene | ENST00000263088, ENST00000572940, | ENST00000318074, ENST00000543823, ENST00000490170, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 7 X 7 X 5=245 |
| # samples | 2 | 7 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(7/245*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PLD2 [Title/Abstract] AND SYTL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SYTL1 | GO:0006887 | exocytosis | 18266782 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI909908 | PLD2 | chr17 | 4721440 | + | SYTL1 | chr1 | 27676205 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000263088 | ENST00000318074 | PLD2 | chr17 | 4721440 | + | SYTL1 | chr1 | 27676205 | - |
| intron-3CDS | ENST00000263088 | ENST00000543823 | PLD2 | chr17 | 4721440 | + | SYTL1 | chr1 | 27676205 | - |
| intron-3UTR | ENST00000263088 | ENST00000490170 | PLD2 | chr17 | 4721440 | + | SYTL1 | chr1 | 27676205 | - |
| intron-3CDS | ENST00000572940 | ENST00000318074 | PLD2 | chr17 | 4721440 | + | SYTL1 | chr1 | 27676205 | - |
| intron-3CDS | ENST00000572940 | ENST00000543823 | PLD2 | chr17 | 4721440 | + | SYTL1 | chr1 | 27676205 | - |
| intron-3UTR | ENST00000572940 | ENST00000490170 | PLD2 | chr17 | 4721440 | + | SYTL1 | chr1 | 27676205 | - |
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FusionProtFeatures for PLD2_SYTL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PLD2 | SYTL1 |