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Fusion gene ID: 27528 |
FusionGeneSummary for PLD1_FNDC3B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PLD1_FNDC3B | Fusion gene ID: 27528 | Hgene | Tgene | Gene symbol | PLD1 | FNDC3B | Gene ID | 5589 | 64778 |
| Gene name | protein kinase C substrate 80K-H | fibronectin type III domain containing 3B | |
| Synonyms | AGE-R2|G19P1|GIIB|PCLD|PCLD1|PKCSH|PLD1|VASAP-60 | FAD104|PRO4979|YVTM2421 | |
| Cytomap | 19p13.2 | 3q26.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glucosidase 2 subunit betaAGE-binding receptor 2advanced glycation end-product receptor 2glucosidase II subunit betahepatocystinprotein kinase C substrate 60.1 kDa protein heavy chainprotein kinase C substrate, 80 Kda protein | fibronectin type III domain-containing protein 3BHCV NS5A-binding protein 37factor for adipocyte differentiation 104 | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | Q13393 | Q53EP0 | |
| Ensembl transtripts involved in fusion gene | ENST00000356327, ENST00000351298, ENST00000342215, ENST00000340989, ENST00000497307, | ENST00000415807, ENST00000336824, ENST00000416957, ENST00000392699, ENST00000421757, ENST00000423424, ENST00000476794, | |
| Fusion gene scores | * DoF score | 5 X 4 X 4=80 | 11 X 13 X 5=715 |
| # samples | 5 | 14 | |
| ** MAII score | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(14/715*10)=-2.35251641472079 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PLD1 [Title/Abstract] AND FNDC3B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-63-A5MP-01A | PLD1 | chr3 | 171528189 | - | FNDC3B | chr3 | 171830242 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-5UTR | ENST00000356327 | ENST00000415807 | PLD1 | chr3 | 171528189 | - | FNDC3B | chr3 | 171830242 | + |
| 5UTR-5UTR | ENST00000356327 | ENST00000336824 | PLD1 | chr3 | 171528189 | - | FNDC3B | chr3 | 171830242 | + |
| 5UTR-5UTR | ENST00000356327 | ENST00000416957 | PLD1 | chr3 | 171528189 | - | FNDC3B | chr3 | 171830242 | + |
| 5UTR-5UTR | ENST00000356327 | ENST00000392699 | PLD1 | chr3 | 171528189 | - | FNDC3B | chr3 | 171830242 | + |
| 5UTR-5UTR | ENST00000356327 | ENST00000421757 | PLD1 | chr3 | 171528189 | - | FNDC3B | chr3 | 171830242 | + |
| 5UTR-5UTR | ENST00000356327 | ENST00000423424 | PLD1 | chr3 | 171528189 | - | FNDC3B | chr3 | 171830242 | + |
| 5UTR-intron | ENST00000356327 | ENST00000476794 | PLD1 | chr3 | 171528189 | - | FNDC3B | chr3 | 171830242 | + |
| 5UTR-5UTR | ENST00000351298 | ENST00000415807 | PLD1 | chr3 | 171528189 | - | FNDC3B | chr3 | 171830242 | + |
| 5UTR-5UTR | ENST00000351298 | ENST00000336824 | PLD1 | chr3 | 171528189 | - | FNDC3B | chr3 | 171830242 | + |
| 5UTR-5UTR | ENST00000351298 | ENST00000416957 | PLD1 | chr3 | 171528189 | - | FNDC3B | chr3 | 171830242 | + |
| 5UTR-5UTR | ENST00000351298 | ENST00000392699 | PLD1 | chr3 | 171528189 | - | FNDC3B | chr3 | 171830242 | + |
| 5UTR-5UTR | ENST00000351298 | ENST00000421757 | PLD1 | chr3 | 171528189 | - | FNDC3B | chr3 | 171830242 | + |
| 5UTR-5UTR | ENST00000351298 | ENST00000423424 | PLD1 | chr3 | 171528189 | - | FNDC3B | chr3 | 171830242 | + |
| 5UTR-intron | ENST00000351298 | ENST00000476794 | PLD1 | chr3 | 171528189 | - | FNDC3B | chr3 | 171830242 | + |
| 5UTR-5UTR | ENST00000342215 | ENST00000415807 | PLD1 | chr3 | 171528189 | - | FNDC3B | chr3 | 171830242 | + |
| 5UTR-5UTR | ENST00000342215 | ENST00000336824 | PLD1 | chr3 | 171528189 | - | FNDC3B | chr3 | 171830242 | + |
| 5UTR-5UTR | ENST00000342215 | ENST00000416957 | PLD1 | chr3 | 171528189 | - | FNDC3B | chr3 | 171830242 | + |
| 5UTR-5UTR | ENST00000342215 | ENST00000392699 | PLD1 | chr3 | 171528189 | - | FNDC3B | chr3 | 171830242 | + |
| 5UTR-5UTR | ENST00000342215 | ENST00000421757 | PLD1 | chr3 | 171528189 | - | FNDC3B | chr3 | 171830242 | + |
| 5UTR-5UTR | ENST00000342215 | ENST00000423424 | PLD1 | chr3 | 171528189 | - | FNDC3B | chr3 | 171830242 | + |
| 5UTR-intron | ENST00000342215 | ENST00000476794 | PLD1 | chr3 | 171528189 | - | FNDC3B | chr3 | 171830242 | + |
| 5UTR-5UTR | ENST00000340989 | ENST00000415807 | PLD1 | chr3 | 171528189 | - | FNDC3B | chr3 | 171830242 | + |
| 5UTR-5UTR | ENST00000340989 | ENST00000336824 | PLD1 | chr3 | 171528189 | - | FNDC3B | chr3 | 171830242 | + |
| 5UTR-5UTR | ENST00000340989 | ENST00000416957 | PLD1 | chr3 | 171528189 | - | FNDC3B | chr3 | 171830242 | + |
| 5UTR-5UTR | ENST00000340989 | ENST00000392699 | PLD1 | chr3 | 171528189 | - | FNDC3B | chr3 | 171830242 | + |
| 5UTR-5UTR | ENST00000340989 | ENST00000421757 | PLD1 | chr3 | 171528189 | - | FNDC3B | chr3 | 171830242 | + |
| 5UTR-5UTR | ENST00000340989 | ENST00000423424 | PLD1 | chr3 | 171528189 | - | FNDC3B | chr3 | 171830242 | + |
| 5UTR-intron | ENST00000340989 | ENST00000476794 | PLD1 | chr3 | 171528189 | - | FNDC3B | chr3 | 171830242 | + |
| 5UTR-5UTR | ENST00000497307 | ENST00000415807 | PLD1 | chr3 | 171528189 | - | FNDC3B | chr3 | 171830242 | + |
| 5UTR-5UTR | ENST00000497307 | ENST00000336824 | PLD1 | chr3 | 171528189 | - | FNDC3B | chr3 | 171830242 | + |
| 5UTR-5UTR | ENST00000497307 | ENST00000416957 | PLD1 | chr3 | 171528189 | - | FNDC3B | chr3 | 171830242 | + |
| 5UTR-5UTR | ENST00000497307 | ENST00000392699 | PLD1 | chr3 | 171528189 | - | FNDC3B | chr3 | 171830242 | + |
| 5UTR-5UTR | ENST00000497307 | ENST00000421757 | PLD1 | chr3 | 171528189 | - | FNDC3B | chr3 | 171830242 | + |
| 5UTR-5UTR | ENST00000497307 | ENST00000423424 | PLD1 | chr3 | 171528189 | - | FNDC3B | chr3 | 171830242 | + |
| 5UTR-intron | ENST00000497307 | ENST00000476794 | PLD1 | chr3 | 171528189 | - | FNDC3B | chr3 | 171830242 | + |
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FusionProtFeatures for PLD1_FNDC3B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PLD1 | FNDC3B |