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Fusion gene ID: 27521

FusionGeneSummary for PLCL2_SH3BGR

Fusion gene summary

Fusion gene information	Fusion gene name: PLCL2_SH3BGR
	Fusion gene ID: 27521
		Hgene	Tgene
	Gene symbol	PLCL2	SH3BGR
	Gene ID	23228	6451
	Gene name	phospholipase C like 2	SH3 domain binding glutamate rich protein like
	Synonyms	PLCE2	HEL-S-115\|SH3BGR
	Cytomap	3p24.3	Xq21.1
	Type of gene	protein-coding	protein-coding
	Description	inactive phospholipase C-like protein 2PLC-L(2)PLC-L2PLC-epsilon-2phospholipase C-L2phospholipase C-epsilon-2	SH3 domain-binding glutamic acid-rich-like proteinSH3 domain binding glutamic acid-rich protein likeSH3-binding domain glutamic acid-rich protein likeepididymis secretory protein Li 115
	Modification date	20180519	20180522
	UniProtAcc	Q9UPR0	P55822
	Ensembl transtripts involved in fusion gene	ENST00000460467, ENST00000396755, ENST00000418129, ENST00000432376,	ENST00000380637, ENST00000380634, ENST00000458295, ENST00000380631, ENST00000333634,
Fusion gene scores	* DoF score	2 X 2 X 2=8	4 X 4 X 4=64
	# samples	2	4
	** MAII score	log2(2/8*10)=1.32192809488736	log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PLCL2 [Title/Abstract] AND SH3BGR [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BF574371	PLCL2	chr3	17066191	+	SH3BGR	chr21	40880928	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000460467	ENST00000380637	PLCL2	chr3	17066191	+	SH3BGR	chr21	40880928	+
intron-3CDS	ENST00000460467	ENST00000380634	PLCL2	chr3	17066191	+	SH3BGR	chr21	40880928	+
intron-3CDS	ENST00000460467	ENST00000458295	PLCL2	chr3	17066191	+	SH3BGR	chr21	40880928	+
intron-3CDS	ENST00000460467	ENST00000380631	PLCL2	chr3	17066191	+	SH3BGR	chr21	40880928	+
intron-3CDS	ENST00000460467	ENST00000333634	PLCL2	chr3	17066191	+	SH3BGR	chr21	40880928	+
intron-3CDS	ENST00000396755	ENST00000380637	PLCL2	chr3	17066191	+	SH3BGR	chr21	40880928	+
intron-3CDS	ENST00000396755	ENST00000380634	PLCL2	chr3	17066191	+	SH3BGR	chr21	40880928	+
intron-3CDS	ENST00000396755	ENST00000458295	PLCL2	chr3	17066191	+	SH3BGR	chr21	40880928	+
intron-3CDS	ENST00000396755	ENST00000380631	PLCL2	chr3	17066191	+	SH3BGR	chr21	40880928	+
intron-3CDS	ENST00000396755	ENST00000333634	PLCL2	chr3	17066191	+	SH3BGR	chr21	40880928	+
intron-3CDS	ENST00000418129	ENST00000380637	PLCL2	chr3	17066191	+	SH3BGR	chr21	40880928	+
intron-3CDS	ENST00000418129	ENST00000380634	PLCL2	chr3	17066191	+	SH3BGR	chr21	40880928	+
intron-3CDS	ENST00000418129	ENST00000458295	PLCL2	chr3	17066191	+	SH3BGR	chr21	40880928	+
intron-3CDS	ENST00000418129	ENST00000380631	PLCL2	chr3	17066191	+	SH3BGR	chr21	40880928	+
intron-3CDS	ENST00000418129	ENST00000333634	PLCL2	chr3	17066191	+	SH3BGR	chr21	40880928	+
intron-3CDS	ENST00000432376	ENST00000380637	PLCL2	chr3	17066191	+	SH3BGR	chr21	40880928	+
intron-3CDS	ENST00000432376	ENST00000380634	PLCL2	chr3	17066191	+	SH3BGR	chr21	40880928	+
intron-3CDS	ENST00000432376	ENST00000458295	PLCL2	chr3	17066191	+	SH3BGR	chr21	40880928	+
intron-3CDS	ENST00000432376	ENST00000380631	PLCL2	chr3	17066191	+	SH3BGR	chr21	40880928	+
intron-3CDS	ENST00000432376	ENST00000333634	PLCL2	chr3	17066191	+	SH3BGR	chr21	40880928	+

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FusionProtFeatures for PLCL2_SH3BGR

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
PLCL2 Q9UPR0	SH3BGR P55822

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Fusion gene ID: 27521

FusionGeneSummary for PLCL2_SH3BGR

FusionProtFeatures for PLCL2_SH3BGR