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Fusion gene ID: 27512 |
FusionGeneSummary for PLCG2_CMIP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PLCG2_CMIP | Fusion gene ID: 27512 | Hgene | Tgene | Gene symbol | PLCG2 | CMIP | Gene ID | 5336 | 80790 |
| Gene name | phospholipase C gamma 2 | c-Maf inducing protein | |
| Synonyms | APLAID|FCAS3|PLC-IV|PLC-gamma-2 | TCMIP | |
| Cytomap | 16q23.3 | 16q23.2-q23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2phosphoinositide phospholipase C-gamma-2phospholipase C, gamma 2 (phosphatidylinositol-specific)phospholipase C-IV | C-Maf-inducing proteintc-Mip | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | P16885 | Q8IY22 | |
| Ensembl transtripts involved in fusion gene | ENST00000359376, ENST00000565400, | ENST00000537098, ENST00000539778, ENST00000566513, ENST00000398040, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 4 X 5 X 2=40 |
| # samples | 2 | 5 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PLCG2 [Title/Abstract] AND CMIP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PLCG2 | GO:0006661 | phosphatidylinositol biosynthetic process | 11606584|12181444 |
| Hgene | PLCG2 | GO:0051209 | release of sequestered calcium ion into cytosol | 11606584 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | CESC | TCGA-C5-A8YR-01A | PLCG2 | chr16 | 81819787 | + | CMIP | chr16 | 81733290 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000359376 | ENST00000537098 | PLCG2 | chr16 | 81819787 | + | CMIP | chr16 | 81733290 | + |
| Frame-shift | ENST00000359376 | ENST00000539778 | PLCG2 | chr16 | 81819787 | + | CMIP | chr16 | 81733290 | + |
| 5CDS-3UTR | ENST00000359376 | ENST00000566513 | PLCG2 | chr16 | 81819787 | + | CMIP | chr16 | 81733290 | + |
| 5CDS-3UTR | ENST00000359376 | ENST00000398040 | PLCG2 | chr16 | 81819787 | + | CMIP | chr16 | 81733290 | + |
| intron-3CDS | ENST00000565400 | ENST00000537098 | PLCG2 | chr16 | 81819787 | + | CMIP | chr16 | 81733290 | + |
| intron-3CDS | ENST00000565400 | ENST00000539778 | PLCG2 | chr16 | 81819787 | + | CMIP | chr16 | 81733290 | + |
| intron-3UTR | ENST00000565400 | ENST00000566513 | PLCG2 | chr16 | 81819787 | + | CMIP | chr16 | 81733290 | + |
| intron-3UTR | ENST00000565400 | ENST00000398040 | PLCG2 | chr16 | 81819787 | + | CMIP | chr16 | 81733290 | + |
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FusionProtFeatures for PLCG2_CMIP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PLCG2 | CMIP |