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Fusion gene ID: 27511 |
FusionGeneSummary for PLCG1_TAF4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PLCG1_TAF4 | Fusion gene ID: 27511 | Hgene | Tgene | Gene symbol | PLCG1 | TAF4 | Gene ID | 5335 | 6874 |
| Gene name | phospholipase C gamma 1 | TATA-box binding protein associated factor 4 | |
| Synonyms | NCKAP3|PLC-II|PLC1|PLC148|PLCgamma1 | TAF2C|TAF2C1|TAF4A|TAFII130|TAFII135 | |
| Cytomap | 20q12 | 20q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-11-phosphatidyl-D-myo-inositol-4,5-bisphosphatePLC-148PLC-gamma-1inositoltrisphosphohydrolasemonophosphatidylinositol phosphodiesterasephosphatidylinositol phospholipase Cphosphoinosit | transcription initiation factor TFIID subunit 4RNA polymerase II TBP-associated factor subunit CTAF(II)130TAF(II)135TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDaTAF4A RNA polymerase II, TATA box binding protein (TBP | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | P19174 | O00268 | |
| Ensembl transtripts involved in fusion gene | ENST00000244007, ENST00000373272, ENST00000373271, ENST00000608689, | ENST00000252996, ENST00000609045, | |
| Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 5 X 6 X 2=60 |
| # samples | 4 | 12 | |
| ** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(12/60*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PLCG1 [Title/Abstract] AND TAF4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PLCG1 | GO:0043536 | positive regulation of blood vessel endothelial cell migration | 20011604 |
| Hgene | PLCG1 | GO:0045766 | positive regulation of angiogenesis | 20011604 |
| Hgene | PLCG1 | GO:0071364 | cellular response to epidermal growth factor stimulus | 17229814 |
| Tgene | TAF4 | GO:0006352 | DNA-templated transcription, initiation | 9603525 |
| Tgene | TAF4 | GO:0006367 | transcription initiation from RNA polymerase II promoter | 9603525 |
| Tgene | TAF4 | GO:0045893 | positive regulation of transcription, DNA-templated | 12771217 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-EW-A2FW-01A | PLCG1 | chr20 | 39766498 | + | TAF4 | chr20 | 60584230 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000244007 | ENST00000252996 | PLCG1 | chr20 | 39766498 | + | TAF4 | chr20 | 60584230 | - |
| 5CDS-intron | ENST00000244007 | ENST00000609045 | PLCG1 | chr20 | 39766498 | + | TAF4 | chr20 | 60584230 | - |
| Frame-shift | ENST00000373272 | ENST00000252996 | PLCG1 | chr20 | 39766498 | + | TAF4 | chr20 | 60584230 | - |
| 5CDS-intron | ENST00000373272 | ENST00000609045 | PLCG1 | chr20 | 39766498 | + | TAF4 | chr20 | 60584230 | - |
| Frame-shift | ENST00000373271 | ENST00000252996 | PLCG1 | chr20 | 39766498 | + | TAF4 | chr20 | 60584230 | - |
| 5CDS-intron | ENST00000373271 | ENST00000609045 | PLCG1 | chr20 | 39766498 | + | TAF4 | chr20 | 60584230 | - |
| intron-3CDS | ENST00000608689 | ENST00000252996 | PLCG1 | chr20 | 39766498 | + | TAF4 | chr20 | 60584230 | - |
| intron-intron | ENST00000608689 | ENST00000609045 | PLCG1 | chr20 | 39766498 | + | TAF4 | chr20 | 60584230 | - |
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FusionProtFeatures for PLCG1_TAF4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PLCG1 | TAF4 |