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Fusion gene ID: 27492 |
FusionGeneSummary for PLCB3_BAD |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PLCB3_BAD | Fusion gene ID: 27492 | Hgene | Tgene | Gene symbol | PLCB3 | BAD | Gene ID | 5331 | 572 |
| Gene name | phospholipase C beta 3 | BCL2 associated agonist of cell death | |
| Synonyms | - | BBC2|BCL2L8 | |
| Cytomap | 11q13.1 | 11q13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3PLC beta 3phosphoinositide phospholipase C-beta-3phospholipase C, beta 3 (phosphatidylinositol-specific) | bcl2-associated agonist of cell deathBCL-X/BCL-2 binding proteinBCL2-antagonist of cell death proteinBCL2-binding component 6BCL2-binding proteinbcl-2-binding component 6bcl-2-like protein 8bcl-XL/Bcl-2-associated death promoterbcl2 antagonist of | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q01970 | Q92934 | |
| Ensembl transtripts involved in fusion gene | ENST00000279230, ENST00000540288, ENST00000325234, | ENST00000394532, ENST00000309032, ENST00000544785, ENST00000394531, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 6 X 5 X 6=180 |
| # samples | 4 | 9 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/180*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PLCB3 [Title/Abstract] AND BAD [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PLCB3 | GO:0003073 | regulation of systemic arterial blood pressure | 18468998 |
| Tgene | BAD | GO:0006915 | apoptotic process | 19667065 |
| Tgene | BAD | GO:0043065 | positive regulation of apoptotic process | 9388232 |
| Tgene | BAD | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 18402937 |
| Tgene | BAD | GO:0045862 | positive regulation of proteolysis | 18387192 |
| Tgene | BAD | GO:0046931 | pore complex assembly | 19667065|21081150 |
| Tgene | BAD | GO:0071316 | cellular response to nicotine | 18676776 |
| Tgene | BAD | GO:0097202 | activation of cysteine-type endopeptidase activity | 18387192 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A8-A06R-01A | PLCB3 | chr11 | 64027706 | + | BAD | chr11 | 64039275 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000279230 | ENST00000394532 | PLCB3 | chr11 | 64027706 | + | BAD | chr11 | 64039275 | - |
| Frame-shift | ENST00000279230 | ENST00000309032 | PLCB3 | chr11 | 64027706 | + | BAD | chr11 | 64039275 | - |
| 5CDS-intron | ENST00000279230 | ENST00000544785 | PLCB3 | chr11 | 64027706 | + | BAD | chr11 | 64039275 | - |
| 5CDS-intron | ENST00000279230 | ENST00000394531 | PLCB3 | chr11 | 64027706 | + | BAD | chr11 | 64039275 | - |
| Frame-shift | ENST00000540288 | ENST00000394532 | PLCB3 | chr11 | 64027706 | + | BAD | chr11 | 64039275 | - |
| Frame-shift | ENST00000540288 | ENST00000309032 | PLCB3 | chr11 | 64027706 | + | BAD | chr11 | 64039275 | - |
| 5CDS-intron | ENST00000540288 | ENST00000544785 | PLCB3 | chr11 | 64027706 | + | BAD | chr11 | 64039275 | - |
| 5CDS-intron | ENST00000540288 | ENST00000394531 | PLCB3 | chr11 | 64027706 | + | BAD | chr11 | 64039275 | - |
| Frame-shift | ENST00000325234 | ENST00000394532 | PLCB3 | chr11 | 64027706 | + | BAD | chr11 | 64039275 | - |
| Frame-shift | ENST00000325234 | ENST00000309032 | PLCB3 | chr11 | 64027706 | + | BAD | chr11 | 64039275 | - |
| 5CDS-intron | ENST00000325234 | ENST00000544785 | PLCB3 | chr11 | 64027706 | + | BAD | chr11 | 64039275 | - |
| 5CDS-intron | ENST00000325234 | ENST00000394531 | PLCB3 | chr11 | 64027706 | + | BAD | chr11 | 64039275 | - |
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FusionProtFeatures for PLCB3_BAD |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PLCB3 | BAD |