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Fusion gene ID: 27455

FusionGeneSummary for PLAGL1_BAI3

Fusion gene summary

Fusion gene information	Fusion gene name: PLAGL1_BAI3
	Fusion gene ID: 27455
		Hgene	Tgene
	Gene symbol	PLAGL1	BAI3
	Gene ID	5325	577
	Gene name	PLAG1 like zinc finger 1	adhesion G protein-coupled receptor B3
	Synonyms	LOT1\|ZAC\|ZAC1	BAI3
	Cytomap	6q24.2	6q12-q13
	Type of gene	protein-coding	protein-coding
	Description	zinc finger protein PLAGL1PLAG-like 1lost on transformation 1pleiomorphic adenoma gene-like 1tumor suppressor ZAC	adhesion G protein-coupled receptor B3brain-specific angiogenesis inhibitor 3dJ91B17.1 (brain-specific angiogenesis inhibitor 3)
	Modification date	20180523	20180523
	UniProtAcc	Q9UM63
	Ensembl transtripts involved in fusion gene	ENST00000429150, ENST00000416623, ENST00000392309, ENST00000392307, ENST00000437412, ENST00000444202, ENST00000493898, ENST00000360537, ENST00000354765, ENST00000367572, ENST00000367571,	ENST00000370598, ENST00000238918, ENST00000546190,
Fusion gene scores	* DoF score	4 X 4 X 3=48	4 X 3 X 4=48
	# samples	3	4
	** MAII score	log2(3/48*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: PLAGL1 [Title/Abstract] AND BAI3 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PLAGL1	GO:0045944	positive regulation of transcription by RNA polymerase II	9671765\|15888726
Tgene	BAI3	GO:0007520	myoblast fusion	24567399

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	BLCA	TCGA-GV-A40E-01A	PLAGL1	chr6	144290044	-	BAI3	chr6	70034764	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000429150	ENST00000370598	PLAGL1	chr6	144290044	-	BAI3	chr6	70034764	+
5UTR-3CDS	ENST00000429150	ENST00000238918	PLAGL1	chr6	144290044	-	BAI3	chr6	70034764	+
5UTR-intron	ENST00000429150	ENST00000546190	PLAGL1	chr6	144290044	-	BAI3	chr6	70034764	+
5UTR-3CDS	ENST00000416623	ENST00000370598	PLAGL1	chr6	144290044	-	BAI3	chr6	70034764	+
5UTR-3CDS	ENST00000416623	ENST00000238918	PLAGL1	chr6	144290044	-	BAI3	chr6	70034764	+
5UTR-intron	ENST00000416623	ENST00000546190	PLAGL1	chr6	144290044	-	BAI3	chr6	70034764	+
5UTR-3CDS	ENST00000392309	ENST00000370598	PLAGL1	chr6	144290044	-	BAI3	chr6	70034764	+
5UTR-3CDS	ENST00000392309	ENST00000238918	PLAGL1	chr6	144290044	-	BAI3	chr6	70034764	+
5UTR-intron	ENST00000392309	ENST00000546190	PLAGL1	chr6	144290044	-	BAI3	chr6	70034764	+
5UTR-3CDS	ENST00000392307	ENST00000370598	PLAGL1	chr6	144290044	-	BAI3	chr6	70034764	+
5UTR-3CDS	ENST00000392307	ENST00000238918	PLAGL1	chr6	144290044	-	BAI3	chr6	70034764	+
5UTR-intron	ENST00000392307	ENST00000546190	PLAGL1	chr6	144290044	-	BAI3	chr6	70034764	+
5UTR-3CDS	ENST00000437412	ENST00000370598	PLAGL1	chr6	144290044	-	BAI3	chr6	70034764	+
5UTR-3CDS	ENST00000437412	ENST00000238918	PLAGL1	chr6	144290044	-	BAI3	chr6	70034764	+
5UTR-intron	ENST00000437412	ENST00000546190	PLAGL1	chr6	144290044	-	BAI3	chr6	70034764	+
5UTR-3CDS	ENST00000444202	ENST00000370598	PLAGL1	chr6	144290044	-	BAI3	chr6	70034764	+
5UTR-3CDS	ENST00000444202	ENST00000238918	PLAGL1	chr6	144290044	-	BAI3	chr6	70034764	+
5UTR-intron	ENST00000444202	ENST00000546190	PLAGL1	chr6	144290044	-	BAI3	chr6	70034764	+
intron-3CDS	ENST00000493898	ENST00000370598	PLAGL1	chr6	144290044	-	BAI3	chr6	70034764	+
intron-3CDS	ENST00000493898	ENST00000238918	PLAGL1	chr6	144290044	-	BAI3	chr6	70034764	+
intron-intron	ENST00000493898	ENST00000546190	PLAGL1	chr6	144290044	-	BAI3	chr6	70034764	+
5UTR-3CDS	ENST00000360537	ENST00000370598	PLAGL1	chr6	144290044	-	BAI3	chr6	70034764	+
5UTR-3CDS	ENST00000360537	ENST00000238918	PLAGL1	chr6	144290044	-	BAI3	chr6	70034764	+
5UTR-intron	ENST00000360537	ENST00000546190	PLAGL1	chr6	144290044	-	BAI3	chr6	70034764	+
5UTR-3CDS	ENST00000354765	ENST00000370598	PLAGL1	chr6	144290044	-	BAI3	chr6	70034764	+
5UTR-3CDS	ENST00000354765	ENST00000238918	PLAGL1	chr6	144290044	-	BAI3	chr6	70034764	+
5UTR-intron	ENST00000354765	ENST00000546190	PLAGL1	chr6	144290044	-	BAI3	chr6	70034764	+
intron-3CDS	ENST00000367572	ENST00000370598	PLAGL1	chr6	144290044	-	BAI3	chr6	70034764	+
intron-3CDS	ENST00000367572	ENST00000238918	PLAGL1	chr6	144290044	-	BAI3	chr6	70034764	+
intron-intron	ENST00000367572	ENST00000546190	PLAGL1	chr6	144290044	-	BAI3	chr6	70034764	+
intron-3CDS	ENST00000367571	ENST00000370598	PLAGL1	chr6	144290044	-	BAI3	chr6	70034764	+
intron-3CDS	ENST00000367571	ENST00000238918	PLAGL1	chr6	144290044	-	BAI3	chr6	70034764	+
intron-intron	ENST00000367571	ENST00000546190	PLAGL1	chr6	144290044	-	BAI3	chr6	70034764	+

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FusionProtFeatures for PLAGL1_BAI3

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
PLAGL1 Q9UM63	BAI3

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Fusion gene ID: 27455

FusionGeneSummary for PLAGL1_BAI3

FusionProtFeatures for PLAGL1_BAI3