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Fusion gene ID: 27390 |
FusionGeneSummary for PKM_TUSC3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PKM_TUSC3 | Fusion gene ID: 27390 | Hgene | Tgene | Gene symbol | PKM | TUSC3 | Gene ID | 5315 | 7991 |
| Gene name | pyruvate kinase M1/2 | tumor suppressor candidate 3 | |
| Synonyms | CTHBP|HEL-S-30|OIP3|PK3|PKM2|TCB|THBP1 | D8S1992|M33|MRT22|MRT7|MagT2|N33|OST3A | |
| Cytomap | 15q23 | 8p22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | pyruvate kinase PKMOIP-3OPA-interacting protein 3PK, muscle typecytosolic thyroid hormone-binding proteinepididymis secretory protein Li 30p58pyruvate kinase 2/3pyruvate kinase isozymes M1/M2pyruvate kinase muscle isozymepyruvate kinase, muscle | tumor suppressor candidate 3magnesium uptake/transporter TUSC3oligosaccharyltransferase 3 homolog Aputative prostate cancer tumor suppressor | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P14618 | Q13454 | |
| Ensembl transtripts involved in fusion gene | ENST00000319622, ENST00000565184, ENST00000389093, ENST00000335181, ENST00000568883, ENST00000449901, ENST00000565154, ENST00000568459, | ENST00000503191, ENST00000382020, ENST00000506802, ENST00000509380, ENST00000503731, | |
| Fusion gene scores | * DoF score | 17 X 21 X 3=1071 | 4 X 4 X 2=32 |
| # samples | 21 | 4 | |
| ** MAII score | log2(21/1071*10)=-2.35049724708413 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PKM [Title/Abstract] AND TUSC3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PKM | GO:0012501 | programmed cell death | 17308100 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF204709 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-intron | ENST00000319622 | ENST00000503191 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| 5UTR-5UTR | ENST00000319622 | ENST00000382020 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| 5UTR-5UTR | ENST00000319622 | ENST00000506802 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| 5UTR-5UTR | ENST00000319622 | ENST00000509380 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| 5UTR-5UTR | ENST00000319622 | ENST00000503731 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| 5UTR-intron | ENST00000565184 | ENST00000503191 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| 5UTR-5UTR | ENST00000565184 | ENST00000382020 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| 5UTR-5UTR | ENST00000565184 | ENST00000506802 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| 5UTR-5UTR | ENST00000565184 | ENST00000509380 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| 5UTR-5UTR | ENST00000565184 | ENST00000503731 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| intron-intron | ENST00000389093 | ENST00000503191 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| intron-5UTR | ENST00000389093 | ENST00000382020 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| intron-5UTR | ENST00000389093 | ENST00000506802 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| intron-5UTR | ENST00000389093 | ENST00000509380 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| intron-5UTR | ENST00000389093 | ENST00000503731 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| intron-intron | ENST00000335181 | ENST00000503191 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| intron-5UTR | ENST00000335181 | ENST00000382020 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| intron-5UTR | ENST00000335181 | ENST00000506802 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| intron-5UTR | ENST00000335181 | ENST00000509380 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| intron-5UTR | ENST00000335181 | ENST00000503731 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| intron-intron | ENST00000568883 | ENST00000503191 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| intron-5UTR | ENST00000568883 | ENST00000382020 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| intron-5UTR | ENST00000568883 | ENST00000506802 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| intron-5UTR | ENST00000568883 | ENST00000509380 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| intron-5UTR | ENST00000568883 | ENST00000503731 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| intron-intron | ENST00000449901 | ENST00000503191 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| intron-5UTR | ENST00000449901 | ENST00000382020 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| intron-5UTR | ENST00000449901 | ENST00000506802 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| intron-5UTR | ENST00000449901 | ENST00000509380 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| intron-5UTR | ENST00000449901 | ENST00000503731 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| 5UTR-intron | ENST00000565154 | ENST00000503191 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| 5UTR-5UTR | ENST00000565154 | ENST00000382020 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| 5UTR-5UTR | ENST00000565154 | ENST00000506802 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| 5UTR-5UTR | ENST00000565154 | ENST00000509380 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| 5UTR-5UTR | ENST00000565154 | ENST00000503731 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| intron-intron | ENST00000568459 | ENST00000503191 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| intron-5UTR | ENST00000568459 | ENST00000382020 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| intron-5UTR | ENST00000568459 | ENST00000506802 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| intron-5UTR | ENST00000568459 | ENST00000509380 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
| intron-5UTR | ENST00000568459 | ENST00000503731 | PKM | chr15 | 72523241 | + | TUSC3 | chr8 | 15397794 | + |
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FusionProtFeatures for PKM_TUSC3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PKM | TUSC3 |