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Fusion gene ID: 27373 |
FusionGeneSummary for PKMYT1_FLYWCH1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PKMYT1_FLYWCH1 | Fusion gene ID: 27373 | Hgene | Tgene | Gene symbol | PKMYT1 | FLYWCH1 | Gene ID | 9088 | 84256 |
| Gene name | protein kinase, membrane associated tyrosine/threonine 1 | FLYWCH-type zinc finger 1 | |
| Synonyms | MYT1|PPP1R126 | - | |
| Cytomap | 16p13.3 | 16p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinasemyt1 kinaseprotein phosphatase 1, regulatory subunit 126 | FLYWCH-type zinc finger-containing protein 1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q99640 | Q4VC44 | |
| Ensembl transtripts involved in fusion gene | ENST00000571102, ENST00000431515, ENST00000440027, ENST00000262300, ENST00000574385, ENST00000574730, ENST00000573944, | ENST00000253928, ENST00000399667, ENST00000416288, ENST00000570752, | |
| Fusion gene scores | * DoF score | 3 X 4 X 4=48 | 1 X 1 X 1=1 |
| # samples | 4 | 1 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: PKMYT1 [Title/Abstract] AND FLYWCH1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PKMYT1 | GO:0010923 | negative regulation of phosphatase activity | 19389623 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | CESC | TCGA-EK-A2PI-01A | PKMYT1 | chr16 | 3019889 | - | FLYWCH1 | chr16 | 2964177 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-5UTR | ENST00000571102 | ENST00000253928 | PKMYT1 | chr16 | 3019889 | - | FLYWCH1 | chr16 | 2964177 | + |
| 5UTR-5UTR | ENST00000571102 | ENST00000399667 | PKMYT1 | chr16 | 3019889 | - | FLYWCH1 | chr16 | 2964177 | + |
| 5UTR-5UTR | ENST00000571102 | ENST00000416288 | PKMYT1 | chr16 | 3019889 | - | FLYWCH1 | chr16 | 2964177 | + |
| 5UTR-intron | ENST00000571102 | ENST00000570752 | PKMYT1 | chr16 | 3019889 | - | FLYWCH1 | chr16 | 2964177 | + |
| intron-5UTR | ENST00000431515 | ENST00000253928 | PKMYT1 | chr16 | 3019889 | - | FLYWCH1 | chr16 | 2964177 | + |
| intron-5UTR | ENST00000431515 | ENST00000399667 | PKMYT1 | chr16 | 3019889 | - | FLYWCH1 | chr16 | 2964177 | + |
| intron-5UTR | ENST00000431515 | ENST00000416288 | PKMYT1 | chr16 | 3019889 | - | FLYWCH1 | chr16 | 2964177 | + |
| intron-intron | ENST00000431515 | ENST00000570752 | PKMYT1 | chr16 | 3019889 | - | FLYWCH1 | chr16 | 2964177 | + |
| intron-5UTR | ENST00000440027 | ENST00000253928 | PKMYT1 | chr16 | 3019889 | - | FLYWCH1 | chr16 | 2964177 | + |
| intron-5UTR | ENST00000440027 | ENST00000399667 | PKMYT1 | chr16 | 3019889 | - | FLYWCH1 | chr16 | 2964177 | + |
| intron-5UTR | ENST00000440027 | ENST00000416288 | PKMYT1 | chr16 | 3019889 | - | FLYWCH1 | chr16 | 2964177 | + |
| intron-intron | ENST00000440027 | ENST00000570752 | PKMYT1 | chr16 | 3019889 | - | FLYWCH1 | chr16 | 2964177 | + |
| intron-5UTR | ENST00000262300 | ENST00000253928 | PKMYT1 | chr16 | 3019889 | - | FLYWCH1 | chr16 | 2964177 | + |
| intron-5UTR | ENST00000262300 | ENST00000399667 | PKMYT1 | chr16 | 3019889 | - | FLYWCH1 | chr16 | 2964177 | + |
| intron-5UTR | ENST00000262300 | ENST00000416288 | PKMYT1 | chr16 | 3019889 | - | FLYWCH1 | chr16 | 2964177 | + |
| intron-intron | ENST00000262300 | ENST00000570752 | PKMYT1 | chr16 | 3019889 | - | FLYWCH1 | chr16 | 2964177 | + |
| intron-5UTR | ENST00000574385 | ENST00000253928 | PKMYT1 | chr16 | 3019889 | - | FLYWCH1 | chr16 | 2964177 | + |
| intron-5UTR | ENST00000574385 | ENST00000399667 | PKMYT1 | chr16 | 3019889 | - | FLYWCH1 | chr16 | 2964177 | + |
| intron-5UTR | ENST00000574385 | ENST00000416288 | PKMYT1 | chr16 | 3019889 | - | FLYWCH1 | chr16 | 2964177 | + |
| intron-intron | ENST00000574385 | ENST00000570752 | PKMYT1 | chr16 | 3019889 | - | FLYWCH1 | chr16 | 2964177 | + |
| intron-5UTR | ENST00000574730 | ENST00000253928 | PKMYT1 | chr16 | 3019889 | - | FLYWCH1 | chr16 | 2964177 | + |
| intron-5UTR | ENST00000574730 | ENST00000399667 | PKMYT1 | chr16 | 3019889 | - | FLYWCH1 | chr16 | 2964177 | + |
| intron-5UTR | ENST00000574730 | ENST00000416288 | PKMYT1 | chr16 | 3019889 | - | FLYWCH1 | chr16 | 2964177 | + |
| intron-intron | ENST00000574730 | ENST00000570752 | PKMYT1 | chr16 | 3019889 | - | FLYWCH1 | chr16 | 2964177 | + |
| intron-5UTR | ENST00000573944 | ENST00000253928 | PKMYT1 | chr16 | 3019889 | - | FLYWCH1 | chr16 | 2964177 | + |
| intron-5UTR | ENST00000573944 | ENST00000399667 | PKMYT1 | chr16 | 3019889 | - | FLYWCH1 | chr16 | 2964177 | + |
| intron-5UTR | ENST00000573944 | ENST00000416288 | PKMYT1 | chr16 | 3019889 | - | FLYWCH1 | chr16 | 2964177 | + |
| intron-intron | ENST00000573944 | ENST00000570752 | PKMYT1 | chr16 | 3019889 | - | FLYWCH1 | chr16 | 2964177 | + |
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FusionProtFeatures for PKMYT1_FLYWCH1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PKMYT1 | FLYWCH1 |