|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 27349 |
FusionGeneSummary for PJA2_FER |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PJA2_FER | Fusion gene ID: 27349 | Hgene | Tgene | Gene symbol | PJA2 | FER | Gene ID | 9867 | 2241 |
| Gene name | praja ring finger ubiquitin ligase 2 | FER tyrosine kinase | |
| Synonyms | Neurodap1|RNF131 | PPP1R74|TYK3|p94-Fer | |
| Cytomap | 5q21.3 | 5q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 ubiquitin-protein ligase Praja-2RING-type E3 ubiquitin transferase Praja-2praja 2, RING-H2 motif containingpraja ring finger 2, E3 ubiquitin protein ligasepraja2ring finger protein 131 | tyrosine-protein kinase Ferfeline encephalitis virus-related kinase FERfer (fps/fes related) tyrosine kinasefujinami poultry sarcoma/Feline sarcoma-related protein Ferphosphoprotein NCP94protein phosphatase 1, regulatory subunit 74proto-oncogene c-F | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O43164 | P16591 | |
| Ensembl transtripts involved in fusion gene | ENST00000361189, ENST00000361557, ENST00000511624, | ENST00000536402, ENST00000281092, ENST00000502752, ENST00000438717, | |
| Fusion gene scores | * DoF score | 6 X 5 X 3=90 | 3 X 3 X 2=18 |
| # samples | 6 | 3 | |
| ** MAII score | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PJA2 [Title/Abstract] AND FER [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PJA2 | GO:0016567 | protein ubiquitination | 21423175 |
| Tgene | FER | GO:0007260 | tyrosine phosphorylation of STAT protein | 19147545 |
| Tgene | FER | GO:0010591 | regulation of lamellipodium assembly | 19738202 |
| Tgene | FER | GO:0018108 | peptidyl-tyrosine phosphorylation | 12972546|19738202 |
| Tgene | FER | GO:0046777 | protein autophosphorylation | 7623846 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AB636596 | PJA2 | chr5 | 108691615 | - | FER | chr5 | 108373121 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000361189 | ENST00000536402 | PJA2 | chr5 | 108691615 | - | FER | chr5 | 108373121 | + |
| 5CDS-intron | ENST00000361189 | ENST00000281092 | PJA2 | chr5 | 108691615 | - | FER | chr5 | 108373121 | + |
| 5CDS-intron | ENST00000361189 | ENST00000502752 | PJA2 | chr5 | 108691615 | - | FER | chr5 | 108373121 | + |
| 5CDS-intron | ENST00000361189 | ENST00000438717 | PJA2 | chr5 | 108691615 | - | FER | chr5 | 108373121 | + |
| 5CDS-intron | ENST00000361557 | ENST00000536402 | PJA2 | chr5 | 108691615 | - | FER | chr5 | 108373121 | + |
| 5CDS-intron | ENST00000361557 | ENST00000281092 | PJA2 | chr5 | 108691615 | - | FER | chr5 | 108373121 | + |
| 5CDS-intron | ENST00000361557 | ENST00000502752 | PJA2 | chr5 | 108691615 | - | FER | chr5 | 108373121 | + |
| 5CDS-intron | ENST00000361557 | ENST00000438717 | PJA2 | chr5 | 108691615 | - | FER | chr5 | 108373121 | + |
| intron-intron | ENST00000511624 | ENST00000536402 | PJA2 | chr5 | 108691615 | - | FER | chr5 | 108373121 | + |
| intron-intron | ENST00000511624 | ENST00000281092 | PJA2 | chr5 | 108691615 | - | FER | chr5 | 108373121 | + |
| intron-intron | ENST00000511624 | ENST00000502752 | PJA2 | chr5 | 108691615 | - | FER | chr5 | 108373121 | + |
| intron-intron | ENST00000511624 | ENST00000438717 | PJA2 | chr5 | 108691615 | - | FER | chr5 | 108373121 | + |
Top |
FusionProtFeatures for PJA2_FER |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PJA2 | FER |