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Fusion gene ID: 27348 |
FusionGeneSummary for PIWIL4_THRSP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PIWIL4_THRSP | Fusion gene ID: 27348 | Hgene | Tgene | Gene symbol | PIWIL4 | THRSP | Gene ID | 143689 | 7069 |
| Gene name | piwi like RNA-mediated gene silencing 4 | thyroid hormone responsive | |
| Synonyms | HIWI2|MIWI2 | LPGP1|Lpgp|S14|SPOT14|THRP | |
| Cytomap | 11q21 | 11q14.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | piwi-like protein 4piwi-like 4testis tissue sperm-binding protein Li 85P | thyroid hormone-inducible hepatic proteinSPOT14 homologlipogenic protein 1spot 14 proteinthyroid hormone responsive (SPOT14 homolog, rat)thyroid hormone responsive SPOT14 | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q7Z3Z4 | Q92748 | |
| Ensembl transtripts involved in fusion gene | ENST00000299001, ENST00000537419, | ENST00000281030, | |
| Fusion gene scores | * DoF score | 2 X 3 X 2=12 | 9 X 1 X 5=45 |
| # samples | 2 | 9 | |
| ** MAII score | log2(2/12*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/45*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PIWIL4 [Title/Abstract] AND THRSP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A3LT-01A | PIWIL4 | chr11 | 94301974 | + | THRSP | chr11 | 77778705 | + |
| TCGA | LD | SARC | TCGA-DX-A3LT-01A | PIWIL4 | chr11 | 94310658 | + | THRSP | chr11 | 77778705 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000299001 | ENST00000281030 | PIWIL4 | chr11 | 94301974 | + | THRSP | chr11 | 77778705 | + |
| intron-3UTR | ENST00000537419 | ENST00000281030 | PIWIL4 | chr11 | 94301974 | + | THRSP | chr11 | 77778705 | + |
| 5CDS-3UTR | ENST00000299001 | ENST00000281030 | PIWIL4 | chr11 | 94310658 | + | THRSP | chr11 | 77778705 | + |
| intron-3UTR | ENST00000537419 | ENST00000281030 | PIWIL4 | chr11 | 94310658 | + | THRSP | chr11 | 77778705 | + |
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FusionProtFeatures for PIWIL4_THRSP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PIWIL4 | THRSP |