|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 27343 |
FusionGeneSummary for PITX1_SH3BGRL3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PITX1_SH3BGRL3 | Fusion gene ID: 27343 | Hgene | Tgene | Gene symbol | PITX1 | SH3BGRL3 | Gene ID | 5307 | 83442 |
| Gene name | paired like homeodomain 1 | SH3 domain binding glutamate rich protein like 3 | |
| Synonyms | BFT|CCF|LBNBG|POTX|PTX1 | HEL-S-297|SH3BP-1|TIP-B1 | |
| Cytomap | 5q31.1 | 1p36.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | pituitary homeobox 1hindlimb expressed homeobox protein backfoothomeobox protein PITX1paired-like homeodomain transcription factor 1pituitary homeo box 1pituitary otx-related factor | SH3 domain-binding glutamic acid-rich-like protein 3SH3 domain binding glutamic acid-rich protein like 3SH3 domain-binding protein 1SH3BGRL3-like proteinTNF inhibitory proteinepididymis secretory protein Li 297 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P78337 | Q9H299 | |
| Ensembl transtripts involved in fusion gene | ENST00000265340, ENST00000506438, | ENST00000270792, ENST00000319041, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 4 X 4 X 2=32 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PITX1 [Title/Abstract] AND SH3BGRL3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF912850 | PITX1 | chr5 | 134367990 | + | SH3BGRL3 | chr1 | 26607655 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000265340 | ENST00000270792 | PITX1 | chr5 | 134367990 | + | SH3BGRL3 | chr1 | 26607655 | + |
| intron-3UTR | ENST00000265340 | ENST00000319041 | PITX1 | chr5 | 134367990 | + | SH3BGRL3 | chr1 | 26607655 | + |
| intron-3UTR | ENST00000506438 | ENST00000270792 | PITX1 | chr5 | 134367990 | + | SH3BGRL3 | chr1 | 26607655 | + |
| intron-3UTR | ENST00000506438 | ENST00000319041 | PITX1 | chr5 | 134367990 | + | SH3BGRL3 | chr1 | 26607655 | + |
Top |
FusionProtFeatures for PITX1_SH3BGRL3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PITX1 | SH3BGRL3 |