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Fusion gene ID: 27246 |
FusionGeneSummary for PIN4_HDAC8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PIN4_HDAC8 | Fusion gene ID: 27246 | Hgene | Tgene | Gene symbol | PIN4 | HDAC8 | Gene ID | 5303 | 55869 |
| Gene name | peptidylprolyl cis/trans isomerase, NIMA-interacting 4 | histone deacetylase 8 | |
| Synonyms | EPVH|PAR14|PAR17 | CDA07|CDLS5|HD8|HDACL1|MRXS6|RPD3|WTS | |
| Cytomap | Xq13.1 | Xq13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | peptidyl-prolyl cis-trans isomerase NIMA-interacting 4PPIase PIN4eukaryotic parvulin homologhEPVHhPar14hPar17parvulinparvulin-14parvulin-17peptidyl-prolyl cis-trans isomerase Pin4peptidyl-prolyl cis/trans isomerase EPVHprotein (peptidylprolyl c | histone deacetylase 8histone deacetylase-like 1 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9Y237 | Q9BY41 | |
| Ensembl transtripts involved in fusion gene | ENST00000423432, ENST00000218432, ENST00000373669, | ENST00000373583, ENST00000373573, ENST00000373589, ENST00000429103, ENST00000373571, ENST00000439122, ENST00000373560, ENST00000373559, ENST00000373561, ENST00000478743, ENST00000373556, ENST00000373554, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 4 X 2 X 4=32 |
| # samples | 2 | 4 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PIN4 [Title/Abstract] AND HDAC8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | HDAC8 | GO:0031397 | negative regulation of protein ubiquitination | 16809764 |
| Tgene | HDAC8 | GO:0031647 | regulation of protein stability | 16809764 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | STAD | TCGA-BR-7715-01A | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000423432 | ENST00000373583 | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
| 5CDS-intron | ENST00000423432 | ENST00000373573 | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
| 5CDS-intron | ENST00000423432 | ENST00000373589 | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
| 5CDS-intron | ENST00000423432 | ENST00000429103 | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
| 5CDS-intron | ENST00000423432 | ENST00000373571 | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
| 5CDS-intron | ENST00000423432 | ENST00000439122 | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
| 5CDS-intron | ENST00000423432 | ENST00000373560 | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
| 5CDS-intron | ENST00000423432 | ENST00000373559 | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
| 5CDS-intron | ENST00000423432 | ENST00000373561 | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
| 5CDS-intron | ENST00000423432 | ENST00000478743 | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
| 5CDS-intron | ENST00000423432 | ENST00000373556 | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
| 5CDS-intron | ENST00000423432 | ENST00000373554 | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
| 5CDS-intron | ENST00000218432 | ENST00000373583 | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
| 5CDS-intron | ENST00000218432 | ENST00000373573 | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
| 5CDS-intron | ENST00000218432 | ENST00000373589 | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
| 5CDS-intron | ENST00000218432 | ENST00000429103 | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
| 5CDS-intron | ENST00000218432 | ENST00000373571 | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
| 5CDS-intron | ENST00000218432 | ENST00000439122 | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
| 5CDS-intron | ENST00000218432 | ENST00000373560 | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
| 5CDS-intron | ENST00000218432 | ENST00000373559 | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
| 5CDS-intron | ENST00000218432 | ENST00000373561 | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
| 5CDS-intron | ENST00000218432 | ENST00000478743 | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
| 5CDS-intron | ENST00000218432 | ENST00000373556 | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
| 5CDS-intron | ENST00000218432 | ENST00000373554 | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
| 5CDS-intron | ENST00000373669 | ENST00000373583 | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
| 5CDS-intron | ENST00000373669 | ENST00000373573 | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
| 5CDS-intron | ENST00000373669 | ENST00000373589 | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
| 5CDS-intron | ENST00000373669 | ENST00000429103 | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
| 5CDS-intron | ENST00000373669 | ENST00000373571 | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
| 5CDS-intron | ENST00000373669 | ENST00000439122 | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
| 5CDS-intron | ENST00000373669 | ENST00000373560 | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
| 5CDS-intron | ENST00000373669 | ENST00000373559 | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
| 5CDS-intron | ENST00000373669 | ENST00000373561 | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
| 5CDS-intron | ENST00000373669 | ENST00000478743 | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
| 5CDS-intron | ENST00000373669 | ENST00000373556 | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
| 5CDS-intron | ENST00000373669 | ENST00000373554 | PIN4 | chrX | 71416754 | + | HDAC8 | chrX | 71571688 | - |
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FusionProtFeatures for PIN4_HDAC8 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PIN4 | HDAC8 |