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Fusion gene ID: 27222 |
FusionGeneSummary for PIK3R4_PIK3R4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PIK3R4_PIK3R4 | Fusion gene ID: 27222 | Hgene | Tgene | Gene symbol | PIK3R4 | PIK3R4 | Gene ID | 30849 | 30849 |
| Gene name | phosphoinositide-3-kinase regulatory subunit 4 | phosphoinositide-3-kinase regulatory subunit 4 | |
| Synonyms | VPS15|p150 | VPS15|p150 | |
| Cytomap | 3q22.1 | 3q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | phosphoinositide 3-kinase regulatory subunit 4PI3-kinase p150 subunitPI3-kinase regulatory subunit 4phosphatidylinositol 3-kinase-associated p150phosphoinositide 3-kinase adaptor proteinphosphoinositide-3-kinase, regulatory subunit 4, p150 | phosphoinositide 3-kinase regulatory subunit 4PI3-kinase p150 subunitPI3-kinase regulatory subunit 4phosphatidylinositol 3-kinase-associated p150phosphoinositide 3-kinase adaptor proteinphosphoinositide-3-kinase, regulatory subunit 4, p150 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q99570 | Q99570 | |
| Ensembl transtripts involved in fusion gene | ENST00000356763, ENST00000512677, | ENST00000356763, ENST00000512677, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 2 X 2 X 1=4 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: PIK3R4 [Title/Abstract] AND PIK3R4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PIK3R4 | GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity | 21062745 |
| Tgene | PIK3R4 | GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity | 21062745 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI475213 | PIK3R4 | chr3 | 130397958 | + | PIK3R4 | chr3 | 130398031 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000356763 | ENST00000356763 | PIK3R4 | chr3 | 130397958 | + | PIK3R4 | chr3 | 130398031 | - |
| intron-intron | ENST00000356763 | ENST00000512677 | PIK3R4 | chr3 | 130397958 | + | PIK3R4 | chr3 | 130398031 | - |
| intron-3UTR | ENST00000512677 | ENST00000356763 | PIK3R4 | chr3 | 130397958 | + | PIK3R4 | chr3 | 130398031 | - |
| intron-intron | ENST00000512677 | ENST00000512677 | PIK3R4 | chr3 | 130397958 | + | PIK3R4 | chr3 | 130398031 | - |
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FusionProtFeatures for PIK3R4_PIK3R4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PIK3R4 | PIK3R4 |