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Fusion gene ID: 27198 |
FusionGeneSummary for PIK3CB_RASA2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PIK3CB_RASA2 | Fusion gene ID: 27198 | Hgene | Tgene | Gene symbol | PIK3CB | RASA2 | Gene ID | 5291 | 5922 |
| Gene name | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta | RAS p21 protein activator 2 | |
| Synonyms | P110BETA|PI3K|PI3KBETA|PIK3C1 | GAP1M | |
| Cytomap | 3q22.3 | 3q23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformPI3-kinase p110 subunit betaPI3-kinase subunit betaPI3K-betaPtdIns-3-kinase p110phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit betaphosphoinositid | ras GTPase-activating protein 2GTPase-activating protein 1mGTPase-activating protein of RAS | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P42338 | Q15283 | |
| Ensembl transtripts involved in fusion gene | ENST00000477593, ENST00000544716, ENST00000289153, | ENST00000452898, ENST00000286364, ENST00000509118, | |
| Fusion gene scores | * DoF score | 11 X 8 X 9=792 | 2 X 2 X 2=8 |
| # samples | 11 | 2 | |
| ** MAII score | log2(11/792*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: PIK3CB [Title/Abstract] AND RASA2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PIK3CB | GO:0016310 | phosphorylation | 25327288 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-AQ-A7U7-01A | PIK3CB | chr3 | 138383878 | - | RASA2 | chr3 | 141235170 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000477593 | ENST00000452898 | PIK3CB | chr3 | 138383878 | - | RASA2 | chr3 | 141235170 | + |
| Frame-shift | ENST00000477593 | ENST00000286364 | PIK3CB | chr3 | 138383878 | - | RASA2 | chr3 | 141235170 | + |
| 5CDS-intron | ENST00000477593 | ENST00000509118 | PIK3CB | chr3 | 138383878 | - | RASA2 | chr3 | 141235170 | + |
| Frame-shift | ENST00000544716 | ENST00000452898 | PIK3CB | chr3 | 138383878 | - | RASA2 | chr3 | 141235170 | + |
| Frame-shift | ENST00000544716 | ENST00000286364 | PIK3CB | chr3 | 138383878 | - | RASA2 | chr3 | 141235170 | + |
| 5CDS-intron | ENST00000544716 | ENST00000509118 | PIK3CB | chr3 | 138383878 | - | RASA2 | chr3 | 141235170 | + |
| In-frame | ENST00000289153 | ENST00000452898 | PIK3CB | chr3 | 138383878 | - | RASA2 | chr3 | 141235170 | + |
| In-frame | ENST00000289153 | ENST00000286364 | PIK3CB | chr3 | 138383878 | - | RASA2 | chr3 | 141235170 | + |
| 5CDS-intron | ENST00000289153 | ENST00000509118 | PIK3CB | chr3 | 138383878 | - | RASA2 | chr3 | 141235170 | + |
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FusionProtFeatures for PIK3CB_RASA2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PIK3CB | RASA2 |