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Fusion gene ID: 27121 |
FusionGeneSummary for PIEZO1_UBE4B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PIEZO1_UBE4B | Fusion gene ID: 27121 | Hgene | Tgene | Gene symbol | PIEZO1 | UBE4B | Gene ID | 9780 | 10277 |
| Gene name | piezo type mechanosensitive ion channel component 1 | ubiquitination factor E4B | |
| Synonyms | DHS|FAM38A|LMPH3|Mib | E4|HDNB1|UBOX3|UFD2|UFD2A | |
| Cytomap | 16q24.3 | 1p36.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | piezo-type mechanosensitive ion channel component 1family with sequence similarity 38, member Amembrane protein induced by beta-amyloid treatment | ubiquitin conjugation factor E4 BRING-type E3 ubiquitin transferase E4 BUFD2A-III/UBE4B-III splice isoformhomologous to yeast UFD2homozygously deleted in neuroblastoma-1ubiquitin-fusion degradation protein 2ubiquitination factor E4B (UFD2 homolog, y | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q92508 | O95155 | |
| Ensembl transtripts involved in fusion gene | ENST00000301015, ENST00000327397, | ENST00000253251, ENST00000377157, ENST00000343090, ENST00000377153, ENST00000475795, | |
| Fusion gene scores | * DoF score | 7 X 6 X 5=210 | 6 X 6 X 7=252 |
| # samples | 7 | 8 | |
| ** MAII score | log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/252*10)=-1.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PIEZO1 [Title/Abstract] AND UBE4B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | UBE4B | GO:0008626 | granzyme-mediated apoptotic signaling pathway | 11802788 |
| Tgene | UBE4B | GO:0009411 | response to UV | 11802788 |
| Tgene | UBE4B | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 23509263 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF889257 | PIEZO1 | chr16 | 88783465 | - | UBE4B | chr1 | 10155523 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000301015 | ENST00000253251 | PIEZO1 | chr16 | 88783465 | - | UBE4B | chr1 | 10155523 | + |
| intron-5UTR | ENST00000301015 | ENST00000377157 | PIEZO1 | chr16 | 88783465 | - | UBE4B | chr1 | 10155523 | + |
| intron-5UTR | ENST00000301015 | ENST00000343090 | PIEZO1 | chr16 | 88783465 | - | UBE4B | chr1 | 10155523 | + |
| intron-intron | ENST00000301015 | ENST00000377153 | PIEZO1 | chr16 | 88783465 | - | UBE4B | chr1 | 10155523 | + |
| intron-intron | ENST00000301015 | ENST00000475795 | PIEZO1 | chr16 | 88783465 | - | UBE4B | chr1 | 10155523 | + |
| intron-3CDS | ENST00000327397 | ENST00000253251 | PIEZO1 | chr16 | 88783465 | - | UBE4B | chr1 | 10155523 | + |
| intron-5UTR | ENST00000327397 | ENST00000377157 | PIEZO1 | chr16 | 88783465 | - | UBE4B | chr1 | 10155523 | + |
| intron-5UTR | ENST00000327397 | ENST00000343090 | PIEZO1 | chr16 | 88783465 | - | UBE4B | chr1 | 10155523 | + |
| intron-intron | ENST00000327397 | ENST00000377153 | PIEZO1 | chr16 | 88783465 | - | UBE4B | chr1 | 10155523 | + |
| intron-intron | ENST00000327397 | ENST00000475795 | PIEZO1 | chr16 | 88783465 | - | UBE4B | chr1 | 10155523 | + |
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FusionProtFeatures for PIEZO1_UBE4B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PIEZO1 | UBE4B |