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Fusion gene ID: 2712

FusionGeneSummary for ARL15_PARP8

Fusion gene summary

Fusion gene information	Fusion gene name: ARL15_PARP8
	Fusion gene ID: 2712
		Hgene	Tgene
	Gene symbol	ARL15	PARP8
	Gene ID	54622	79668
	Gene name	ADP ribosylation factor like GTPase 15	poly(ADP-ribose) polymerase family member 8
	Synonyms	ARFRP2	ARTD16\|pART16
	Cytomap	5q11.2	5q11.1
	Type of gene	protein-coding	protein-coding
	Description	ADP-ribosylation factor-like protein 15ADP-ribosylation factor-like 15ADP-ribosylation factor-related protein 2ARF-related protein 2	poly [ADP-ribose] polymerase 8ADP-ribosyltransferase diphtheria toxin-like 16
	Modification date	20180519	20180523
	UniProtAcc	Q9NXU5	Q8N3A8
	Ensembl transtripts involved in fusion gene	ENST00000502271, ENST00000504924, ENST00000510591, ENST00000507646,	ENST00000514342, ENST00000505697, ENST00000511363, ENST00000503750, ENST00000281631, ENST00000514067, ENST00000505554, ENST00000513738, ENST00000503665,
Fusion gene scores	* DoF score	11 X 9 X 5=495	5 X 3 X 4=60
	# samples	11	5
	** MAII score	log2(11/495*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ARL15 [Title/Abstract] AND PARP8 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	SARC	TCGA-DX-A1KX-01A	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-5UTR	ENST00000502271	ENST00000514342	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+
5UTR-5UTR	ENST00000502271	ENST00000505697	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+
5UTR-3UTR	ENST00000502271	ENST00000511363	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+
5UTR-3UTR	ENST00000502271	ENST00000503750	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+
5UTR-3UTR	ENST00000502271	ENST00000281631	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+
5UTR-3UTR	ENST00000502271	ENST00000514067	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+
5UTR-3UTR	ENST00000502271	ENST00000505554	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+
5UTR-intron	ENST00000502271	ENST00000513738	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+
5UTR-intron	ENST00000502271	ENST00000503665	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+
5CDS-5UTR	ENST00000504924	ENST00000514342	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+
5CDS-5UTR	ENST00000504924	ENST00000505697	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+
5CDS-3UTR	ENST00000504924	ENST00000511363	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+
5CDS-3UTR	ENST00000504924	ENST00000503750	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+
5CDS-3UTR	ENST00000504924	ENST00000281631	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+
5CDS-3UTR	ENST00000504924	ENST00000514067	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+
5CDS-3UTR	ENST00000504924	ENST00000505554	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+
5CDS-intron	ENST00000504924	ENST00000513738	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+
5CDS-intron	ENST00000504924	ENST00000503665	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+
intron-5UTR	ENST00000510591	ENST00000514342	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+
intron-5UTR	ENST00000510591	ENST00000505697	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+
intron-3UTR	ENST00000510591	ENST00000511363	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+
intron-3UTR	ENST00000510591	ENST00000503750	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+
intron-3UTR	ENST00000510591	ENST00000281631	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+
intron-3UTR	ENST00000510591	ENST00000514067	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+
intron-3UTR	ENST00000510591	ENST00000505554	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+
intron-intron	ENST00000510591	ENST00000513738	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+
intron-intron	ENST00000510591	ENST00000503665	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+
5CDS-5UTR	ENST00000507646	ENST00000514342	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+
5CDS-5UTR	ENST00000507646	ENST00000505697	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+
5CDS-3UTR	ENST00000507646	ENST00000511363	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+
5CDS-3UTR	ENST00000507646	ENST00000503750	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+
5CDS-3UTR	ENST00000507646	ENST00000281631	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+
5CDS-3UTR	ENST00000507646	ENST00000514067	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+
5CDS-3UTR	ENST00000507646	ENST00000505554	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+
5CDS-intron	ENST00000507646	ENST00000513738	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+
5CDS-intron	ENST00000507646	ENST00000503665	ARL15	chr5	53606262	-	PARP8	chr5	50045985	+

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FusionProtFeatures for ARL15_PARP8

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ARL15 Q9NXU5	PARP8 Q8N3A8

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Fusion gene ID: 2712

FusionGeneSummary for ARL15_PARP8

FusionProtFeatures for ARL15_PARP8