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Fusion gene ID: 27083 |
FusionGeneSummary for PIAS3_C12orf45 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PIAS3_C12orf45 | Fusion gene ID: 27083 | Hgene | Tgene | Gene symbol | PIAS3 | C12orf45 | Gene ID | 10401 | 121053 |
| Gene name | protein inhibitor of activated STAT 3 | chromosome 12 open reading frame 45 | |
| Synonyms | ZMIZ5 | - | |
| Cytomap | 1q21.1 | 12q23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | E3 SUMO-protein ligase PIAS3E3 SUMO-protein transferase PIAS3protein inhibitor of activated STAT protein 3zinc finger, MIZ-type containing 5 | uncharacterized protein C12orf45 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9Y6X2 | Q8N5I9 | |
| Ensembl transtripts involved in fusion gene | ENST00000369299, ENST00000393045, ENST00000369298, | ENST00000552951, ENST00000280749, ENST00000548583, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 2 X 2 X 2=8 |
| # samples | 4 | 2 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: PIAS3 [Title/Abstract] AND C12orf45 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PIAS3 | GO:0033234 | negative regulation of protein sumoylation | 24651376 |
| Hgene | PIAS3 | GO:0033235 | positive regulation of protein sumoylation | 17696781|21965678 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BU608702 | PIAS3 | chr1 | 145585975 | - | C12orf45 | chr12 | 105388298 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000369299 | ENST00000552951 | PIAS3 | chr1 | 145585975 | - | C12orf45 | chr12 | 105388298 | + |
| intron-3UTR | ENST00000369299 | ENST00000280749 | PIAS3 | chr1 | 145585975 | - | C12orf45 | chr12 | 105388298 | + |
| intron-3UTR | ENST00000369299 | ENST00000548583 | PIAS3 | chr1 | 145585975 | - | C12orf45 | chr12 | 105388298 | + |
| 3UTR-3CDS | ENST00000393045 | ENST00000552951 | PIAS3 | chr1 | 145585975 | - | C12orf45 | chr12 | 105388298 | + |
| 3UTR-3UTR | ENST00000393045 | ENST00000280749 | PIAS3 | chr1 | 145585975 | - | C12orf45 | chr12 | 105388298 | + |
| 3UTR-3UTR | ENST00000393045 | ENST00000548583 | PIAS3 | chr1 | 145585975 | - | C12orf45 | chr12 | 105388298 | + |
| 3UTR-3CDS | ENST00000369298 | ENST00000552951 | PIAS3 | chr1 | 145585975 | - | C12orf45 | chr12 | 105388298 | + |
| 3UTR-3UTR | ENST00000369298 | ENST00000280749 | PIAS3 | chr1 | 145585975 | - | C12orf45 | chr12 | 105388298 | + |
| 3UTR-3UTR | ENST00000369298 | ENST00000548583 | PIAS3 | chr1 | 145585975 | - | C12orf45 | chr12 | 105388298 | + |
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FusionProtFeatures for PIAS3_C12orf45 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PIAS3 | C12orf45 |