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Fusion gene ID: 27072 |
FusionGeneSummary for PI4KB_SYT11 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PI4KB_SYT11 | Fusion gene ID: 27072 | Hgene | Tgene | Gene symbol | PI4KB | SYT11 | Gene ID | 5298 | 91683 |
| Gene name | phosphatidylinositol 4-kinase beta | synaptotagmin 12 | |
| Synonyms | NPIK|PI4K-BETA|PI4K92|PI4KBETA|PI4KIIIBETA|PIK4CB | SYT11|sytXII | |
| Cytomap | 1q21.3 | 11q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | phosphatidylinositol 4-kinase betaPtdIns 4-kinase betaphosphatidylinositol 4-kinase, catalytic, betaphosphatidylinositol 4-kinase, wortmannin-sensitivetype III phosphatidylinositol 4-kinase beta | synaptotagmin-12synaptotagmin-XII | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UBF8 | Q9BT88 | |
| Ensembl transtripts involved in fusion gene | ENST00000368874, ENST00000271657, ENST00000368875, ENST00000368873, ENST00000529142, ENST00000368872, | ENST00000368324, ENST00000539162, | |
| Fusion gene scores | * DoF score | 3 X 5 X 5=75 | 4 X 1 X 4=16 |
| # samples | 5 | 4 | |
| ** MAII score | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PI4KB [Title/Abstract] AND SYT11 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-86-A4P7-01A | PI4KB | chr1 | 151299747 | - | SYT11 | chr1 | 155850291 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000368874 | ENST00000368324 | PI4KB | chr1 | 151299747 | - | SYT11 | chr1 | 155850291 | + |
| 5UTR-5UTR | ENST00000368874 | ENST00000539162 | PI4KB | chr1 | 151299747 | - | SYT11 | chr1 | 155850291 | + |
| intron-3CDS | ENST00000271657 | ENST00000368324 | PI4KB | chr1 | 151299747 | - | SYT11 | chr1 | 155850291 | + |
| intron-5UTR | ENST00000271657 | ENST00000539162 | PI4KB | chr1 | 151299747 | - | SYT11 | chr1 | 155850291 | + |
| 5UTR-3CDS | ENST00000368875 | ENST00000368324 | PI4KB | chr1 | 151299747 | - | SYT11 | chr1 | 155850291 | + |
| 5UTR-5UTR | ENST00000368875 | ENST00000539162 | PI4KB | chr1 | 151299747 | - | SYT11 | chr1 | 155850291 | + |
| 5UTR-3CDS | ENST00000368873 | ENST00000368324 | PI4KB | chr1 | 151299747 | - | SYT11 | chr1 | 155850291 | + |
| 5UTR-5UTR | ENST00000368873 | ENST00000539162 | PI4KB | chr1 | 151299747 | - | SYT11 | chr1 | 155850291 | + |
| 5UTR-3CDS | ENST00000529142 | ENST00000368324 | PI4KB | chr1 | 151299747 | - | SYT11 | chr1 | 155850291 | + |
| 5UTR-5UTR | ENST00000529142 | ENST00000539162 | PI4KB | chr1 | 151299747 | - | SYT11 | chr1 | 155850291 | + |
| 5UTR-3CDS | ENST00000368872 | ENST00000368324 | PI4KB | chr1 | 151299747 | - | SYT11 | chr1 | 155850291 | + |
| 5UTR-5UTR | ENST00000368872 | ENST00000539162 | PI4KB | chr1 | 151299747 | - | SYT11 | chr1 | 155850291 | + |
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FusionProtFeatures for PI4KB_SYT11 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PI4KB | SYT11 |