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Fusion gene ID: 27064 |
FusionGeneSummary for PI4KA_RREB1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PI4KA_RREB1 | Fusion gene ID: 27064 | Hgene | Tgene | Gene symbol | PI4KA | RREB1 | Gene ID | 5297 | 6239 |
| Gene name | phosphatidylinositol 4-kinase alpha | ras responsive element binding protein 1 | |
| Synonyms | PI4K-ALPHA|PIK4CA|PMGYCHA|pi4K230 | FINB|HNT|LZ321|RREB-1|Zep-1 | |
| Cytomap | 22q11.21 | 6p24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | phosphatidylinositol 4-kinase alphaPI4-kinase alphaphosphatidylinositol 4-kinase 230phosphatidylinositol 4-kinase III alphaphosphatidylinositol 4-kinase IIII+/-phosphatidylinositol 4-kinase, catalytic, alphaphosphatidylinositol 4-kinase, type III, a | ras-responsive element-binding protein 1DNA-binding proteinfinger protein in nuclear bodieshindsight homolograf-responsive zinc finger protein LZ321zinc finger motif enhancer-binding protein 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P42356 | Q92766 | |
| Ensembl transtripts involved in fusion gene | ENST00000255882, ENST00000572273, ENST00000414196, ENST00000466162, | ENST00000379933, ENST00000379938, ENST00000334984, ENST00000349384, | |
| Fusion gene scores | * DoF score | 15 X 8 X 10=1200 | 9 X 7 X 4=252 |
| # samples | 21 | 9 | |
| ** MAII score | log2(21/1200*10)=-2.51457317282976 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/252*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PI4KA [Title/Abstract] AND RREB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PI4KA | GO:0016310 | phosphorylation | 25327288 |
| Tgene | RREB1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 8816445 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-21-1081-01A | PI4KA | chr22 | 21188850 | - | RREB1 | chr6 | 7211037 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000255882 | ENST00000379933 | PI4KA | chr22 | 21188850 | - | RREB1 | chr6 | 7211037 | + |
| Frame-shift | ENST00000255882 | ENST00000379938 | PI4KA | chr22 | 21188850 | - | RREB1 | chr6 | 7211037 | + |
| Frame-shift | ENST00000255882 | ENST00000334984 | PI4KA | chr22 | 21188850 | - | RREB1 | chr6 | 7211037 | + |
| Frame-shift | ENST00000255882 | ENST00000349384 | PI4KA | chr22 | 21188850 | - | RREB1 | chr6 | 7211037 | + |
| In-frame | ENST00000572273 | ENST00000379933 | PI4KA | chr22 | 21188850 | - | RREB1 | chr6 | 7211037 | + |
| In-frame | ENST00000572273 | ENST00000379938 | PI4KA | chr22 | 21188850 | - | RREB1 | chr6 | 7211037 | + |
| In-frame | ENST00000572273 | ENST00000334984 | PI4KA | chr22 | 21188850 | - | RREB1 | chr6 | 7211037 | + |
| In-frame | ENST00000572273 | ENST00000349384 | PI4KA | chr22 | 21188850 | - | RREB1 | chr6 | 7211037 | + |
| intron-3CDS | ENST00000414196 | ENST00000379933 | PI4KA | chr22 | 21188850 | - | RREB1 | chr6 | 7211037 | + |
| intron-3CDS | ENST00000414196 | ENST00000379938 | PI4KA | chr22 | 21188850 | - | RREB1 | chr6 | 7211037 | + |
| intron-3CDS | ENST00000414196 | ENST00000334984 | PI4KA | chr22 | 21188850 | - | RREB1 | chr6 | 7211037 | + |
| intron-3CDS | ENST00000414196 | ENST00000349384 | PI4KA | chr22 | 21188850 | - | RREB1 | chr6 | 7211037 | + |
| intron-3CDS | ENST00000466162 | ENST00000379933 | PI4KA | chr22 | 21188850 | - | RREB1 | chr6 | 7211037 | + |
| intron-3CDS | ENST00000466162 | ENST00000379938 | PI4KA | chr22 | 21188850 | - | RREB1 | chr6 | 7211037 | + |
| intron-3CDS | ENST00000466162 | ENST00000334984 | PI4KA | chr22 | 21188850 | - | RREB1 | chr6 | 7211037 | + |
| intron-3CDS | ENST00000466162 | ENST00000349384 | PI4KA | chr22 | 21188850 | - | RREB1 | chr6 | 7211037 | + |
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FusionProtFeatures for PI4KA_RREB1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PI4KA | RREB1 |