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Fusion gene ID: 27032 |
FusionGeneSummary for PHTF2_RAB1A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PHTF2_RAB1A | Fusion gene ID: 27032 | Hgene | Tgene | Gene symbol | PHTF2 | RAB1A | Gene ID | 57157 | 5861 |
| Gene name | putative homeodomain transcription factor 2 | RAB1A, member RAS oncogene family | |
| Synonyms | - | RAB1|YPT1 | |
| Cytomap | 7q11.23-q21.11 | 2p14 | |
| Type of gene | protein-coding | protein-coding | |
| Description | putative homeodomain transcription factor 2 | ras-related protein Rab-1AGTP binding protein Rab1aRAB1, member RAS oncogene familyRab GTPase YPT1 homologYPT1-related protein | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8N3S3 | P62820 | |
| Ensembl transtripts involved in fusion gene | ENST00000422959, ENST00000307305, ENST00000424760, ENST00000415251, ENST00000275575, ENST00000450574, ENST00000416283, ENST00000248550, ENST00000454592, | ENST00000494188, ENST00000409892, ENST00000409784, ENST00000398529, ENST00000409751, ENST00000260638, ENST00000356214, | |
| Fusion gene scores | * DoF score | 5 X 4 X 4=80 | 6 X 4 X 6=144 |
| # samples | 5 | 7 | |
| ** MAII score | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/144*10)=-1.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PHTF2 [Title/Abstract] AND RAB1A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AR-A0U4-01A | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000422959 | ENST00000494188 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000422959 | ENST00000409892 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000422959 | ENST00000409784 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000422959 | ENST00000398529 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000422959 | ENST00000409751 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000422959 | ENST00000260638 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000422959 | ENST00000356214 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000307305 | ENST00000494188 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000307305 | ENST00000409892 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000307305 | ENST00000409784 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000307305 | ENST00000398529 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000307305 | ENST00000409751 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000307305 | ENST00000260638 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000307305 | ENST00000356214 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000424760 | ENST00000494188 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000424760 | ENST00000409892 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000424760 | ENST00000409784 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000424760 | ENST00000398529 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000424760 | ENST00000409751 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000424760 | ENST00000260638 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000424760 | ENST00000356214 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000415251 | ENST00000494188 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000415251 | ENST00000409892 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000415251 | ENST00000409784 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000415251 | ENST00000398529 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000415251 | ENST00000409751 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000415251 | ENST00000260638 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000415251 | ENST00000356214 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000275575 | ENST00000494188 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000275575 | ENST00000409892 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000275575 | ENST00000409784 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000275575 | ENST00000398529 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000275575 | ENST00000409751 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000275575 | ENST00000260638 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000275575 | ENST00000356214 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000450574 | ENST00000494188 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000450574 | ENST00000409892 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000450574 | ENST00000409784 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000450574 | ENST00000398529 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000450574 | ENST00000409751 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000450574 | ENST00000260638 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000450574 | ENST00000356214 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000416283 | ENST00000494188 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000416283 | ENST00000409892 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000416283 | ENST00000409784 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000416283 | ENST00000398529 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000416283 | ENST00000409751 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000416283 | ENST00000260638 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000416283 | ENST00000356214 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000248550 | ENST00000494188 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000248550 | ENST00000409892 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000248550 | ENST00000409784 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000248550 | ENST00000398529 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000248550 | ENST00000409751 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000248550 | ENST00000260638 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| 5CDS-intron | ENST00000248550 | ENST00000356214 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| intron-intron | ENST00000454592 | ENST00000494188 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| intron-intron | ENST00000454592 | ENST00000409892 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| intron-intron | ENST00000454592 | ENST00000409784 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| intron-intron | ENST00000454592 | ENST00000398529 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| intron-intron | ENST00000454592 | ENST00000409751 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| intron-intron | ENST00000454592 | ENST00000260638 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
| intron-intron | ENST00000454592 | ENST00000356214 | PHTF2 | chr7 | 77469617 | + | RAB1A | chr2 | 65316204 | - |
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FusionProtFeatures for PHTF2_RAB1A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PHTF2 | RAB1A |