FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 27017

FusionGeneSummary for PHLPP2_KIF22

check button Fusion gene summary
Fusion gene informationFusion gene name: PHLPP2_KIF22
Fusion gene ID: 27017
HgeneTgene
Gene symbol

PHLPP2

KIF22

Gene ID

23035

3835

Gene namePH domain and leucine rich repeat protein phosphatase 2kinesin family member 22
SynonymsPHLPPL|PPM3BA-328A3.2|KID|KNSL4|OBP|OBP-1|OBP-2|SEMDJL2
Cytomap

16q22.2

16p11.2

Type of geneprotein-codingprotein-coding
DescriptionPH domain leucine-rich repeat-containing protein phosphatase 2protein phosphatase, Mg2+/Mn2+ dependent 3Bkinesin-like protein KIF22kinesin-like DNA-binding protein pseudogenekinesin-like protein 4oriP binding proteinorigin of plasmid DNA replication-binding protein
Modification date2018052320180523
UniProtAcc

Q6ZVD8

Q14807

Ensembl transtripts involved in fusion geneENST00000540628, ENST00000360429, 
ENST00000568954, ENST00000393524, 
ENST00000356272, ENST00000567016, 
ENST00000561482, ENST00000160827, 
ENST00000400750, ENST00000400751, 
ENST00000569382, ENST00000563263, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 2 X 2=12
# samples 35
** MAII scorelog2(3/8*10)=1.90689059560852log2(5/12*10)=2.05889368905357
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PHLPP2 [Title/Abstract] AND KIF22 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-97-A4M1-01APHLPP2chr16

71710350

-KIF22chr16

29808214

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000540628ENST00000561482PHLPP2chr16

71710350

-KIF22chr16

29808214

+
intron-5UTRENST00000540628ENST00000160827PHLPP2chr16

71710350

-KIF22chr16

29808214

+
intron-5UTRENST00000540628ENST00000400750PHLPP2chr16

71710350

-KIF22chr16

29808214

+
intron-5UTRENST00000540628ENST00000400751PHLPP2chr16

71710350

-KIF22chr16

29808214

+
intron-5UTRENST00000540628ENST00000569382PHLPP2chr16

71710350

-KIF22chr16

29808214

+
intron-intronENST00000540628ENST00000563263PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000360429ENST00000561482PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000360429ENST00000160827PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000360429ENST00000400750PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000360429ENST00000400751PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000360429ENST00000569382PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-intronENST00000360429ENST00000563263PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000568954ENST00000561482PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000568954ENST00000160827PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000568954ENST00000400750PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000568954ENST00000400751PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000568954ENST00000569382PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-intronENST00000568954ENST00000563263PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000393524ENST00000561482PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000393524ENST00000160827PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000393524ENST00000400750PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000393524ENST00000400751PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000393524ENST00000569382PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-intronENST00000393524ENST00000563263PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000356272ENST00000561482PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000356272ENST00000160827PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000356272ENST00000400750PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000356272ENST00000400751PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000356272ENST00000569382PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-intronENST00000356272ENST00000563263PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000567016ENST00000561482PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000567016ENST00000160827PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000567016ENST00000400750PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000567016ENST00000400751PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-5UTRENST00000567016ENST00000569382PHLPP2chr16

71710350

-KIF22chr16

29808214

+
5CDS-intronENST00000567016ENST00000563263PHLPP2chr16

71710350

-KIF22chr16

29808214

+

Top

FusionProtFeatures for PHLPP2_KIF22


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PHLPP2

Q6ZVD8

KIF22

Q14807