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Fusion gene ID: 26942 |
FusionGeneSummary for PHF21A_TMEM123 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PHF21A_TMEM123 | Fusion gene ID: 26942 | Hgene | Tgene | Gene symbol | PHF21A | TMEM123 | Gene ID | 51317 | 114908 |
| Gene name | PHD finger protein 21A | transmembrane protein 123 | |
| Synonyms | BHC80|BM-006 | KCT3|PORIMIN|PORMIN | |
| Cytomap | 11p11.2 | 11q22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | PHD finger protein 21ABHC80aBRAF35-HDAC complex protein BHC80BRAF35/HDAC2 complex (80 kDa) | poriminKCT-3keratinocytes associated transmembrane protein 3pro-oncosis receptor inducing membrane injuryserine/threonine-rich receptor | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q96BD5 | Q8N131 | |
| Ensembl transtripts involved in fusion gene | ENST00000257821, ENST00000323180, ENST00000418153, ENST00000527753, | ENST00000361236, ENST00000398136, ENST00000532161, ENST00000525577, | |
| Fusion gene scores | * DoF score | 15 X 7 X 13=1365 | 5 X 4 X 2=40 |
| # samples | 19 | 5 | |
| ** MAII score | log2(19/1365*10)=-2.84482962747627 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PHF21A [Title/Abstract] AND TMEM123 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TMEM123 | GO:0070267 | oncosis | 9600958|11481458 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | CESC | TCGA-EA-A411-01A | PHF21A | chr11 | 46098305 | - | TMEM123 | chr11 | 102272937 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000257821 | ENST00000361236 | PHF21A | chr11 | 46098305 | - | TMEM123 | chr11 | 102272937 | - |
| Frame-shift | ENST00000257821 | ENST00000398136 | PHF21A | chr11 | 46098305 | - | TMEM123 | chr11 | 102272937 | - |
| 5CDS-5UTR | ENST00000257821 | ENST00000532161 | PHF21A | chr11 | 46098305 | - | TMEM123 | chr11 | 102272937 | - |
| 5CDS-5UTR | ENST00000257821 | ENST00000525577 | PHF21A | chr11 | 46098305 | - | TMEM123 | chr11 | 102272937 | - |
| Frame-shift | ENST00000323180 | ENST00000361236 | PHF21A | chr11 | 46098305 | - | TMEM123 | chr11 | 102272937 | - |
| Frame-shift | ENST00000323180 | ENST00000398136 | PHF21A | chr11 | 46098305 | - | TMEM123 | chr11 | 102272937 | - |
| 5CDS-5UTR | ENST00000323180 | ENST00000532161 | PHF21A | chr11 | 46098305 | - | TMEM123 | chr11 | 102272937 | - |
| 5CDS-5UTR | ENST00000323180 | ENST00000525577 | PHF21A | chr11 | 46098305 | - | TMEM123 | chr11 | 102272937 | - |
| Frame-shift | ENST00000418153 | ENST00000361236 | PHF21A | chr11 | 46098305 | - | TMEM123 | chr11 | 102272937 | - |
| Frame-shift | ENST00000418153 | ENST00000398136 | PHF21A | chr11 | 46098305 | - | TMEM123 | chr11 | 102272937 | - |
| 5CDS-5UTR | ENST00000418153 | ENST00000532161 | PHF21A | chr11 | 46098305 | - | TMEM123 | chr11 | 102272937 | - |
| 5CDS-5UTR | ENST00000418153 | ENST00000525577 | PHF21A | chr11 | 46098305 | - | TMEM123 | chr11 | 102272937 | - |
| intron-3CDS | ENST00000527753 | ENST00000361236 | PHF21A | chr11 | 46098305 | - | TMEM123 | chr11 | 102272937 | - |
| intron-3CDS | ENST00000527753 | ENST00000398136 | PHF21A | chr11 | 46098305 | - | TMEM123 | chr11 | 102272937 | - |
| intron-5UTR | ENST00000527753 | ENST00000532161 | PHF21A | chr11 | 46098305 | - | TMEM123 | chr11 | 102272937 | - |
| intron-5UTR | ENST00000527753 | ENST00000525577 | PHF21A | chr11 | 46098305 | - | TMEM123 | chr11 | 102272937 | - |
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FusionProtFeatures for PHF21A_TMEM123 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PHF21A | TMEM123 |