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Fusion gene ID: 26885 |
FusionGeneSummary for PHC3_GNA12 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PHC3_GNA12 | Fusion gene ID: 26885 | Hgene | Tgene | Gene symbol | PHC3 | GNA12 | Gene ID | 80012 | 2768 |
| Gene name | polyhomeotic homolog 3 | G protein subunit alpha 12 | |
| Synonyms | EDR3|HPH3 | NNX3|RMP|gep | |
| Cytomap | 3q26.2 | 7p22.3-p22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | polyhomeotic-like protein 3early development regulator 3early development regulatory protein 3homolog of polyhomeotic 3polyhomeotic like 3 | guanine nucleotide-binding protein subunit alpha-12WUGSC:H_GS165O14.2g alpha-12guanine nucleotide binding protein (G protein) alpha 12 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8NDX5 | Q03113 | |
| Ensembl transtripts involved in fusion gene | ENST00000495893, ENST00000494943, ENST00000467570, ENST00000474275, ENST00000497658, ENST00000481639, | ENST00000275364, ENST00000544127, ENST00000491117, ENST00000407904, ENST00000407653, ENST00000396960, | |
| Fusion gene scores | * DoF score | 10 X 9 X 7=630 | 6 X 5 X 4=120 |
| # samples | 12 | 7 | |
| ** MAII score | log2(12/630*10)=-2.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PHC3 [Title/Abstract] AND GNA12 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-CQ-A4CA-01A | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000495893 | ENST00000275364 | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
| In-frame | ENST00000495893 | ENST00000544127 | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
| 5CDS-intron | ENST00000495893 | ENST00000491117 | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
| 5CDS-intron | ENST00000495893 | ENST00000407904 | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
| 5CDS-intron | ENST00000495893 | ENST00000407653 | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
| 5CDS-intron | ENST00000495893 | ENST00000396960 | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
| In-frame | ENST00000494943 | ENST00000275364 | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
| In-frame | ENST00000494943 | ENST00000544127 | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
| 5CDS-intron | ENST00000494943 | ENST00000491117 | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
| 5CDS-intron | ENST00000494943 | ENST00000407904 | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
| 5CDS-intron | ENST00000494943 | ENST00000407653 | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
| 5CDS-intron | ENST00000494943 | ENST00000396960 | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
| In-frame | ENST00000467570 | ENST00000275364 | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
| In-frame | ENST00000467570 | ENST00000544127 | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
| 5CDS-intron | ENST00000467570 | ENST00000491117 | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
| 5CDS-intron | ENST00000467570 | ENST00000407904 | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
| 5CDS-intron | ENST00000467570 | ENST00000407653 | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
| 5CDS-intron | ENST00000467570 | ENST00000396960 | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
| In-frame | ENST00000474275 | ENST00000275364 | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
| In-frame | ENST00000474275 | ENST00000544127 | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
| 5CDS-intron | ENST00000474275 | ENST00000491117 | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
| 5CDS-intron | ENST00000474275 | ENST00000407904 | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
| 5CDS-intron | ENST00000474275 | ENST00000407653 | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
| 5CDS-intron | ENST00000474275 | ENST00000396960 | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
| In-frame | ENST00000497658 | ENST00000275364 | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
| In-frame | ENST00000497658 | ENST00000544127 | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
| 5CDS-intron | ENST00000497658 | ENST00000491117 | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
| 5CDS-intron | ENST00000497658 | ENST00000407904 | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
| 5CDS-intron | ENST00000497658 | ENST00000407653 | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
| 5CDS-intron | ENST00000497658 | ENST00000396960 | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
| In-frame | ENST00000481639 | ENST00000275364 | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
| In-frame | ENST00000481639 | ENST00000544127 | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
| 5CDS-intron | ENST00000481639 | ENST00000491117 | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
| 5CDS-intron | ENST00000481639 | ENST00000407904 | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
| 5CDS-intron | ENST00000481639 | ENST00000407653 | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
| 5CDS-intron | ENST00000481639 | ENST00000396960 | PHC3 | chr3 | 169896561 | - | GNA12 | chr7 | 2834777 | - |
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FusionProtFeatures for PHC3_GNA12 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PHC3 | GNA12 |