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Fusion gene ID: 26867 |
FusionGeneSummary for PHACTR4_SESN2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PHACTR4_SESN2 | Fusion gene ID: 26867 | Hgene | Tgene | Gene symbol | PHACTR4 | SESN2 | Gene ID | 65979 | 83667 |
| Gene name | phosphatase and actin regulator 4 | sestrin 2 | |
| Synonyms | PPP1R124 | HI95|SES2|SEST2 | |
| Cytomap | 1p35.3 | 1p35.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | phosphatase and actin regulator 4protein phosphatase 1, regulatory subunit 124 | sestrin-2hypoxia induced gene 95hypoxia-induced | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8IZ21 | P58004 | |
| Ensembl transtripts involved in fusion gene | ENST00000373839, ENST00000493669, ENST00000373836, | ENST00000253063, | |
| Fusion gene scores | * DoF score | 6 X 3 X 5=90 | 3 X 3 X 2=18 |
| # samples | 7 | 4 | |
| ** MAII score | log2(7/90*10)=-0.362570079384708 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PHACTR4 [Title/Abstract] AND SESN2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SESN2 | GO:0001932 | regulation of protein phosphorylation | 25040165 |
| Tgene | SESN2 | GO:0098869 | cellular oxidant detoxification | 26612684 |
| Tgene | SESN2 | GO:0098869 | cellular oxidant detoxification | 19113821 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LIHC | TCGA-ZS-A9CF-01A | PHACTR4 | chr1 | 28696336 | + | SESN2 | chr1 | 28595694 | + |
| TCGA | RV | LIHC | TCGA-ZS-A9CF-02A | PHACTR4 | chr1 | 28696336 | + | SESN2 | chr1 | 28595694 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000373839 | ENST00000253063 | PHACTR4 | chr1 | 28696336 | + | SESN2 | chr1 | 28595694 | + |
| 3UTR-3CDS | ENST00000493669 | ENST00000253063 | PHACTR4 | chr1 | 28696336 | + | SESN2 | chr1 | 28595694 | + |
| intron-3CDS | ENST00000373836 | ENST00000253063 | PHACTR4 | chr1 | 28696336 | + | SESN2 | chr1 | 28595694 | + |
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FusionProtFeatures for PHACTR4_SESN2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PHACTR4 | SESN2 |